Cs2CO3 catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates

被引：4

作者：

Jiang, Zi-Yu ^{[1
]}

Huang, Zhe-Yao ^{[1
]}

Yang, Hong ^{[1
]}

Zhou, Lin ^{[1
]}

Li, Qing-Han ^{[1
]}

Zhao, Zhi-Gang ^{[1
]}

机构：

[1] Southwest Minzu Univ, Coll Chem & Environm, Key Lab Gen Chem, Natl Ethn Affairs Commiss, Chengdu 610041, Peoples R China

来源：

RSC ADVANCES | 2022年 / 12卷 / 30期

基金：

中国国家自然科学基金;

关键词：

BASIC IONIC LIQUID; N-ARYLATION; ENANTIOSELECTIVE SYNTHESIS; SUBSTITUTED PYRAZOLES; HETEROCYCLES; POTENT; DISCOVERY; BENZOTRIAZOLE; FLUOROARENES; DERIVATIVES;

D O I：

10.1039/d2ra02314h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient method for the synthesis of azole derivatives via a direct aza-Michael addition of azoles to alpha,beta-unsaturated malonates using Cs2CO3 as a catalyst, has been successfully developed. A series of azole derivatives have been obtained in up to 94% yield and the reaction could be amplified to gram scale in excellent yield in the presence of 10 mol% of Cs2CO3.

引用

页码：19265 / 19269

页数：5

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