Cryptococcal immune reconstitution syndrome during steroid withdrawal treated with hydroxychloroquine

被引:19
作者
Narayanan, Shivakumar [1 ]
Banerjee, Chandralekha [2 ]
Holt, Peter A. [3 ]
机构
[1] Good Samaritan Hosp Maryland, Dept Internal Med, RMB, Baltimore, MD 21239 USA
[2] Good Samaritan Hosp Maryland, Div Infect Dis, Dept Internal Med, Baltimore, MD 21239 USA
[3] Good Samaritan Hosp Maryland, Div Rheumatol, Dept Internal Med, Baltimore, MD 21239 USA
关键词
Cryptococcosis; Immune reconstitution syndrome; Steroid withdrawal; Hypercalcemia; Skin nodules; Hydroxychloroquine; CHLOROQUINE; INFECTION; HYPERCALCEMIA; NEOFORMANS; ALPHA;
D O I
10.1016/j.ijid.2010.09.006
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We present a case report of cryptococcal immune reconstitution syndrome (IRS), in a non HIV infected patient, which we treated with hydroxychloroquine with successful results. We briefly review cryptococcal IRS, possible mechanisms of action of hydroxychloroquine as an immunomodulatory agent, and its potential role in management of IRS. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:E70 / E73
页数:4
相关论文
共 25 条
[1]   METABOLISM OF 25-HYDROXYVITAMIN-D3 BY CULTURED PULMONARY ALVEOLAR MACROPHAGES IN SARCOIDOSIS [J].
ADAMS, JS ;
SHARMA, OP ;
GACAD, MA ;
SINGER, FR .
JOURNAL OF CLINICAL INVESTIGATION, 1983, 72 (05) :1856-1860
[2]   Hypercalcemia associated with infection by Cryptococcus neoformans and Coccidioides immitis [J].
Ali, MY ;
Gopal, KV ;
Llerena, LA ;
Taylor, HC .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1999, 318 (06) :419-423
[3]   Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease [J].
Baddley, J. W. ;
Perfect, J. R. ;
Oster, R. A. ;
Larsen, R. A. ;
Pankey, G. A. ;
Henderson, H. ;
Haas, D. W. ;
Kauffman, C. A. ;
Patel, R. ;
Zaas, A. K. ;
Pappas, P. G. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2008, 27 (10) :937-943
[4]   HYDROXYCHLOROQUINE TREATMENT OF HYPERCALCEMIA IN A PATIENT WITH SARCOIDOSIS UNDERGOING HEMODIALYSIS [J].
BARRE, PE ;
GASCONBARRE, M ;
MEAKINS, JL ;
GOLTZMAN, D .
AMERICAN JOURNAL OF MEDICINE, 1987, 82 (06) :1259-1262
[5]   Cryptococcosis [J].
Chayakulkeeree, Methee ;
Perfect, John R. .
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2006, 20 (03) :507-+
[6]   T cell contributions to the different phases of granuloma formation [J].
Co, DO ;
Hogan, LH ;
Il-Kim, S ;
Sandor, M .
IMMUNOLOGY LETTERS, 2004, 92 (1-2) :135-142
[7]   MECHANISM OF ACTION OF HYDROXYCHLOROQUINE AS AN ANTIRHEUMATIC DRUG [J].
FOX, RI .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 1993, 23 (02) :82-91
[8]   Cryptococcosis: Population-based multistate active surveillance and risk factors in human immunodeficiency virus-infected persons [J].
Hajjeh, RA ;
Conn, LA ;
Stephens, DS ;
Baughman, W ;
Hamill, R ;
Graviss, E ;
Pappas, PG ;
Thomas, C ;
Reingold, A ;
Rothrock, G ;
Hutwagner, LC ;
Schuchat, A ;
Brandt, ME ;
Pinner, RW .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (02) :449-454
[9]   Immune reconstitution in HIV-infected patients [J].
Hirsch, HH ;
Kaufmann, G ;
Sendi, P ;
Battegay, M .
CLINICAL INFECTIOUS DISEASES, 2004, 38 (08) :1159-1166
[10]   Chloroquine inhibits production of TNF-α, IL-1β and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes [J].
Jang, C. -H. ;
Choi, J. -H. ;
Byun, M. -S. ;
Jue, D. -M. .
RHEUMATOLOGY, 2006, 45 (06) :703-710