Iso-, nor-, and dinor-spiculoic acids A, polyketides from the marine sponge Plakortis zyggompha

被引：16

作者：

Berrué, F

Thomas, OP

Fernández, R

Amade, P ^{[1
]}

机构：

[1] UNSA, CNRS, UMR 6001, Chim Bioorgan Lab, F-06108 Nice, France

[2] PharmaMar SA, Dept Med Chem, Madrid 28770, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 04期

关键词：

D O I：

10.1021/np049602c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The new iso-, nor-, and dinor-spiculoic acids A (1, 2, and 3, respectively) with a rare spiculane skeleton were isolated from the marine sponge Plakortis zyggompha, collected in the waters south of Martinique. The structural determination of the compounds was based on 1D and 2D NMR studies and mass spectral determinations. Compounds 1 and 2 showed weak cytotoxicity against the two tumor cell lines A549 and HT29.

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页码：547 / 549

页数：3

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