The De Ritis (aspartate transaminase/alanine transaminase) ratio as a predictor of oncological outcomes in patients after surgery for upper urinary tract urothelial carcinoma

被引：25

作者：

Cho, Yang Hyun ^{[1
]}

Hwang, Jun Eul ^{[2
]}

Chung, Ho Seok ^{[1
]}

Kim, Myung Soo ^{[1
]}

Hwang, Eu Chang ^{[1
]}

Jung, Seung Il ^{[1
]}

Kang, Taek Won ^{[1
]}

Kwon, Dong Deuk ^{[1
]}

Choi, Seock Hwan ^{[3
]}

Kim, Hyun Tae ^{[3
]}

Kim, Tae-Hwan ^{[3
]}

Kwon, Tae Gyun ^{[3
]}

Noh, Joon Hwa ^{[4
]}

Kim, Myung Ki ^{[5
]}

Kim, Chul-Sung ^{[6
]}

Kang, Sung Gu ^{[7
]}

Kang, Seok Ho ^{[7
]}

Cheon, Jun ^{[7
]}

Lee, Chan Ho ^{[8
]}

Ku, Ja Yoon ^{[8
]}

Ha, Hong Koo ^{[8
]}

Tae, Bum Sik ^{[9
]}

Jeong, Chang Wook ^{[9
]}

Ku, Ja Hyeon ^{[9
]}

Kwak, Cheol ^{[9
]}

Kim, Hyeon Hoe ^{[9
]}

机构：

[1] Chonnam Natl Univ, Dept Urol, Sch Med, 42 Jebongro, Gwangju 501757, South Korea

[2] Chonnam Natl Univ, Dept Hematooncol, Sch Med, Gwangju, South Korea

[3] Kyungpook Natl Univ, Dept Urol, Sch Med, Daegu, South Korea

[4] Kwangju Christian Hosp, Dept Urol, Gwangju, South Korea

[5] Chonbuk Natl Univ, Dept Urol, Sch Med, Jeonju, South Korea

[6] Chosun Univ, Dept Urol, Sch Med, Gwangju, South Korea

[7] Korea Univ, Dept Urol, Coll Med, Seoul, South Korea

[8] Pusan Natl Univ, Dept Urol, Sch Med, Busan, South Korea

[9] Seoul Natl Univ, Dept Urol, Coll Med, Seoul, South Korea

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2017年 / 49卷 / 08期

关键词：

Alanine transaminase; Aspartate aminotransferase; Prognosis; Survival; Transitional cell carcinoma; NEUTROPHIL-LYMPHOCYTE RATIO; PROGNOSTIC-FACTORS; CANCER; METASTASES; VALIDATION;

D O I：

10.1007/s11255-017-1613-z

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, several studies have shown that the De Ritis ratio (aspartate transaminase/alanine transaminase) can be a useful prognostic biomarker for certain types of malignant tumors. However, the prognostic value of the De Ritis ratio in patients with upper tract urothelial carcinoma remains largely unknown. The aim of the present study was to evaluate the prognostic significance of the De Ritis ratio in patients who had undergone radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma. In total, 1049 patients who underwent RNU at eight institutions from 2004 to 2015 were reviewed retrospectively. The De Ritis ratio and conventional clinicopathological parameters were analyzed. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Multivariate analysis was carried out using the Cox proportional hazards regression model. De Ritis ratio cutoff values were derived from receiver operating characteristic (ROC) curves. ROC analysis showed the cutoff De Ritis ratio for overall death to be 1.6 (p = 0.002). The cancer-specific survival (CSS) and overall survival (OS) were significantly shorter for patients with a high De Ritis ratio (> 1.6). Multivariate analysis revealed an independent relationship between an increased De Ritis ratio (> 1.6) and shorter CSS (hazard ratio, HR 2.49, 95% confidence interval, CI 1.70-3.64; p = 0.001) and OS (HR 1.84, 95% CI 1.34-2.52; p = 0.001). The De Ritis ratio can be a significant predictor of oncological outcomes in patients with upper urinary tract urothelial carcinoma after surgery.

引用

页码：1383 / 1390

页数：8

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