Microwave-assisted synthesis of 2,5-disubstituted pyrimidine derivatives via Buchwald-Hartwig amination

被引：8
|
作者：
Li, Bo [1 ]
Etheve-Quelquejeu, Melanie [1 ]
Yen-Pon, Expedite [1 ]
Garbay, Christiane [1 ]
Chen, Huixiong [1 ]
机构：
[1] Univ Paris 05, CNRS, UMR8601, Chem RNA,Nucleosides Peptides & Heterocycles, 45 Rue St Peres, F-75006 Paris, France
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 03期
关键词：
Pyrimidine; Pd-catalyzed; C-N cross-coupling; Microwave synthesis; INHIBITORS; POTENT;
D O I：
10.1016/j.tetlet.2019.151406
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various 2,5-disubstituted pyrimidine derivatives were synthesized under microwave irradiation via Buchwald-Hartwig amination. This concise approach provides interesting scaffolds in good to high yields and with large functional group compatibility. These novel chemical entities could be used as building blocks in drug design. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：4
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