Effect of brain-derived neurotrophic factor on the release of substance P from rat spinal cord

被引:16
作者
Meyer-Tuve, A
Malcangio, M
Ebersberger, A
Mazario, J
Schaible, HG
机构
[1] Univ Jena, Inst Physiol, D-07740 Jena, Germany
[2] KCL London, Sensory Funct Ctr Neurosci, London SE1 1UL, England
[3] Univ Alcala de Henares, Dept Fisiol, Madrid 28871, Spain
关键词
BDNF; hyperalgesia; inflammation; neuropeptide; pain; TrkB;
D O I
10.1097/00001756-200101220-00012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Brain-derived neurotrophic factor (BDNF) can produce hyperalgesia in the adult rat. Here we assessed whether changes in the spinal release of the nociceptive peptide substance P (SP) contributes to this effect. Antibody-coated microprobes revealed a significant basal release of SP in the dorsal horn in vivo that was increased following acute knee inflammation. Microinjection of BDNF into the grey matter (0.5 mul, 10(-5) M) altered SP release neither in rats with normal knees nor in rats with inflamed knee joints. In the lumbar dorsal horn slice preparation in vitro, superfusion with BDNF (100 ng/ml) could reduce SP release evoked by electrical dorsal root stimulation without modyfing SP basal outflow. It is unlikely, therefore, that enhanced spinal SP release mediates the hyperalgesic effect of BDNF. NeuroReport 12:21-24 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:21 / 24
页数:4
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