Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy

被引：81
作者：
Gupta, Vijayalaxmi [1 ]
Yull, Fiona [2 ,3 ]
Khabele, Dineo [1 ,4 ]
机构：
[1] Univ Kansas, Div Gynecol Oncol, Dept Obstet & Gynecol, Med Ctr, Kansas City, KS 66160 USA
[2] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA
[3] Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA
[4] Univ Kansas, Canc Ctr, Kansas City, KS 66160 USA
来源：
CANCERS | 2018年 / 10卷 / 10期
关键词：
ovarian cancer; tumor-associated macrophages; peritoneal metastasis; tumor microenvironment; NF-KAPPA-B; INHIBITORY FACTOR LEVELS; T-CELLS; M2; POLARIZATION; EXPRESSION; MOUSE; MICROENVIRONMENT; RECEPTOR; SERUM; LOCALIZATION;
D O I：
10.3390/cancers10100366
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer.
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页数：13
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