NAFLD in the Elderly

被引：86

作者：

Alqahtani, Saleh A. ^{[1
,2
]}

Schattenberg, Joern M. ^{[3
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Liver Transplantat Ctr, Riyadh, Saudi Arabia

[2] Johns Hopkins Univ, Div Gastroenterol & Hepatol, Baltimore, MD USA

[3] Univ Med Ctr, Dept Med 1, Metab Liver Res Program, Mainz, Germany

来源：

CLINICAL INTERVENTIONS IN AGING | 2021年 / 16卷

关键词：

liver disease; aging; fatty liver; NASH; senescence; regeneration; NONALCOHOLIC FATTY LIVER; CHAPERONE-MEDIATED AUTOPHAGY; HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; CELLULAR SENESCENCE; OBETICHOLIC ACID; WEIGHT-LOSS; HEPATOCYTE SENESCENCE; COGNITIVE IMPAIRMENT; HEPATIC STEATOSIS;

D O I：

10.2147/CIA.S295524

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease globally. Current estimates are that 24% of the adult population, thus, one billion individuals worldwide, are affected. Interestingly, the prevalence of fatty liver seems to peak between 40-50 years of age in males and 60-69 years in females, often slightly decreasing in older (>70 years) cohorts. Furthermore, several risk factors for NAFLD development, such as hypertension, diabetes, hyperlipidemia, and obesity are higher in older adults. The diagnosis and management strategies in older adults are sometimes challenging, and certain age specific factors have to be taken into account by healthcare professionals. In this review, we provide an overview of considerations relevant to the management and diagnosis of NAFLD in older adults (age >65 years) and discuss the types of pharmacological interventions available for the management of non-alcoholic steatohepatitis (NASH) in the aging population.

引用

页码：1633 / 1649

页数：17

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