Organometallic peptide NHC complexes of Cp*Rh(III) and arene Ru(II) moieties from L-thiazolylalanine

被引：28
|
作者：
Lemke, Jessica [1 ]
Metzler-Nolte, Nils [1 ]
机构：
[1] Ruhr Univ Bochum, Lehrstuhl Anorgan Chem Bioorgan Chem 1, Fak Chem & Biochem, D-44801 Bochum, Germany
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2011年 / 696卷 / 05期
关键词：
Bioorganometallic chemistry; NHC complexes; Peptide bioconjugates; Rhodium compounds; Ruthenium compounds; Thiamine; Thiazolylalanine; CARBENE COMPLEXES; BIOORGANOMETALLIC CHEMISTRY; MEDICINAL APPLICATIONS; PHOSPHINE COMPLEXES; ANTICANCER AGENTS; CRYSTAL-STRUCTURE; RUTHENIUM; LIGANDS; BIOMOLECULES; ENKEPHALIN;
D O I：
10.1016/j.jorganchem.2010.12.044
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The 3-ethyl thiazolium peptide salts Boc-Thia-Leu-OMe and Boc-Thia-Leu-Phe-OMe based on the unnatural amino acid thiazolylalanine (Thia) have been prepared. After deprotonation, they reacted rapidly via the silver carbene transfer reaction with [ RhCp*Cl-2](2) and [Ru(p-cymene)Cl-2](2) to yield the corresponding thiazole-based carbene complexes 7-10 in acceptable yield. All new compounds were characterized by multinuclear NMR spectroscopy, mass spectrometry, and elemental analysis. These complexes constitute the first examples of thiazolylalanine-2-ylidene metal bioconjugates. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1018 / 1022
页数：5
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