Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms

被引:20
作者
Sakurai, Hiroko [1 ]
Harada, Yuka [1 ,2 ]
Ogata, Yosuke [2 ]
Kagiyama, Yuki [3 ]
Shingai, Naoki [1 ]
Doki, Noriko [4 ]
Ohashi, Kazuteru [4 ]
Kitamura, Toshio [5 ]
Komatsu, Norio [1 ]
Harada, Hironori [1 ,3 ]
机构
[1] Juntendo Univ, Dept Hematol, Sch Med, Tokyo, Japan
[2] Bunkyo Gakuin Univ, Dept Clin Lab Med, Tokyo, Japan
[3] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Lab Oncol, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan
[4] Tokyo Metropolitan Canc & Infect Dis Ctr Komagome, Tokyo, Japan
[5] Univ Tokyo, Inst Med Sci, Div Cellular Therapy, Tokyo, Japan
关键词
ACUTE MYELOID-LEUKEMIA; MYELODYSPLASTIC SYNDROMES; AML1; MUTATIONS; STEM; TRANSCRIPTION; CELLS; GENE;
D O I
10.1182/bloodadvances.2016002725
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1382 / 1386
页数:5
相关论文
共 19 条
[1]   The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].
Arber, Daniel A. ;
Orazi, Attilio ;
Hasserjian, Robert ;
Thiele, Jurgen ;
Borowitz, Michael J. ;
Le Beau, Michelle M. ;
Bloomfield, Clara D. ;
Cazzola, Mario ;
Vardiman, James W. .
BLOOD, 2016, 127 (20) :2391-2405
[2]   Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells [J].
Challen, Grant A. ;
Goodell, Margaret A. .
EXPERIMENTAL HEMATOLOGY, 2010, 38 (05) :403-416
[3]   Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia [J].
Elena, Chiara ;
Galli, Anna ;
Such, Esperanza ;
Meggendorfer, Manja ;
Germing, Ulrich ;
Rizzo, Ettore ;
Cervera, Jose ;
Molteni, Elisabetta ;
Fasan, Annette ;
Schuler, Esther ;
Ambaglio, Ilaria ;
Lopez-Pavia, Maria ;
Zibellini, Silvia ;
Kuendgen, Andrea ;
Travaglino, Erica ;
Sancho-Tello, Reyes ;
Catricala, Silvia ;
Vicente, Ana I. ;
Haferlach, Torsten ;
Haferlach, Claudia ;
Sanz, Guillermo F. ;
Malcovati, Luca ;
Cazzola, Mario .
BLOOD, 2016, 128 (10) :1408-1417
[4]   Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis [J].
Guo, Hong ;
Ma, Ou ;
Speck, Nancy A. ;
Friedman, Alan D. .
BLOOD, 2012, 119 (19) :4408-4418
[5]   The new provisional WHO entity 'RUNX1 mutated AML' shows specific genetics but no prognostic influence of dysplasia [J].
Haferlach, T. ;
Stengel, A. ;
Eckstein, S. ;
Perglerova, K. ;
Alpermann, T. ;
Kern, W. ;
Haferlach, C. ;
Meggendorfer, M. .
LEUKEMIA, 2016, 30 (10) :2109-2112
[6]   Recent advances in myelodysplastic syndromes: Molecular pathogenesis and its implications for targeted therapies [J].
Harada, Hironori ;
Harada, Yuka .
CANCER SCIENCE, 2015, 106 (04) :329-336
[7]   RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes [J].
Harada, Yuka ;
Inoue, Daichi ;
Ding, Ye ;
Imagawa, Jun ;
Doki, Noriko ;
Matsui, Hirotaka ;
Yahata, Takashi ;
Matsushita, Hiromichi ;
Ando, Kiyoshi ;
Sashida, Goro ;
Iwama, Atsushi ;
Kitamura, Toshio ;
Harada, Hironori .
BLOOD, 2013, 121 (17) :3434-3446
[8]   SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition [J].
Kim, Eunhee ;
Ilagan, Janine O. ;
Liang, Yang ;
Daubner, Gerrit M. ;
Lee, Stanley C. -W. ;
Ramakrishnan, Aravind ;
Li, Yue ;
Chung, Young Rock ;
Micol, Jean-Baptiste ;
Murphy, Michele E. ;
Cho, Hana ;
Kim, Min-Kyung ;
Zebari, Ahmad S. ;
Aumann, Shlomzion ;
Park, Christopher Y. ;
Buonamici, Silvia ;
Smith, Peter G. ;
Deeg, H. Joachim ;
Lobry, Camille ;
Aifantis, Iannis ;
Modis, Yorgo ;
Allain, Frederic H. -T. ;
Halene, Stephanie ;
Bradley, Robert K. ;
Abdel-Wahab, Omar .
CANCER CELL, 2015, 27 (05) :617-630
[9]   Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice [J].
Komeno, Yukiko ;
Yan, Ming ;
Matsuura, Shinobu ;
Lam, Kentson ;
Lo, Miao-Chia ;
Huang, Yi-Jou ;
Tenen, Daniel G. ;
Downing, James R. ;
Zhang, Dong-Er .
BLOOD, 2014, 123 (24) :3760-3769
[10]   Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1 [J].
Levanon, D ;
Glusman, C ;
Bangsow, T ;
Ben-Asher, E ;
Male, DA ;
Avidan, N ;
Bangsow, C ;
Hattori, M ;
Taylor, TD ;
Taudien, S ;
Blechschmidt, K ;
Shimizu, N ;
Rosenthal, A ;
Sakaki, Y ;
Lancet, D ;
Groner, Y .
GENE, 2001, 262 (1-2) :23-33