Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment

被引：47
作者：
Boxer, AL
Kramer, JH
Johnston, K
Goldman, J
Finley, R
Miller, BL
机构：
[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
[2] Permanente Med Grp Inc, Dept Genet, San Francisco, CA USA
来源：
NEUROLOGY | 2005年 / 64卷 / 08期
关键词：
D O I：
10.1212/01.WNL.0000158476.74580.A8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
An elevated serum homocysteine level is a risk factor for the development of cognitive impairment. Reported is a late-onset case of hyperhomocystinemia due to a vitamin B-12 metabolic deficit ( cobalamin C) with cognitive impairment, primarily in frontal/executive function. After homocysteine-lowering therapy, the patient's functional and neuropsychological status improved in conjunction with a decrease in leukoariosis on his MRI scan. These findings suggest that homocysteine-related cognitive impairment may be partially reversible.
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收藏
页码：1431 / 1434
页数：4
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