The second PGD2 receptor CRTH2:: structure, properties, and functions in leukocytes

被引：117

作者：

Nagata, K ^{[1
]}

Hirai, H ^{[1
]}

机构：

[1] Bio Med Labs Inc, R&D Ctr, Kawagoe, Saitama 3501101, Japan

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2003年 / 69卷 / 2-3期

关键词：

prostaglandin D-2; G protein-coupled receptor; allergy;

D O I：

10.1016/S0952-3278(03)00078-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandin (PG) D-2 plays a broad range of physiological and pathophysiological functions. Until just a few years ago, it was thought that most of the biological actions of PGD(2) are mediated via the classical PGD(2) receptor DP. Recently, we identified a second PGD(2) receptor, chemoattractant receptor-homologous molecule expressed on T helper (Th)2 cells (CRTH2), with different functions relative to DP. Here, we review the recent findings on the structure, tissue distribution, ligand selectivity, signalling pathways, and functions in leukocytes of this receptor. The data suggest that the PGD(2)/CRTH2 system play important roles in allergic inflammation through its stimulatory effects on Th2 cells, cosinophils, and basophils. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：169 / 177

页数：9

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