Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones

被引：10

作者：

Mumtaz, Saira ^{[1
]}

Robertson, Mark J. ^{[1
]}

Oelgemoller, Michael ^{[1
,2
]}

机构：

[1] James Cook Univ, Coll Sci & Engn, Townsville, Qld 4811, Australia

[2] Univ Ghent, Dept Organ & Macromol Chem, Krijgslaan 281 S4-Bis, B-9000 Ghent, Belgium

来源：

MOLECULES | 2019年 / 24卷 / 24期

基金：

澳大利亚研究理事会;

关键词：

photochemistry; photodecarboxylation; phthalimide; continuous-flow photochemistry; multi-step synthesis; arylmethylene isoindolinones; PHOTODECARBOXYLATIVE ADDITION; PHTHALIMIDES; CARBOXYLATES; MECHANISM;

D O I：

10.3390/molecules24244527

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An effective multi-step continuous flow approach towards N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones, including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochemical-thermal-thermal flow setup rapidly provides the desired target compounds in superior yields and significantly shorter reaction times.

引用

页数：10

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