SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL PYRIMIDINE DERIVATIVES

被引：0
作者：
Kumar, Hemanth [1 ]
Revanasiddappa, B. C. [1 ]
机构：
[1] NGSM Inst Pharmaceut Sci Nitte Deemed Be Univ, Dept Pharmaceut Chem, Mangalore 575018, Karnataka, India
来源：
HETEROCYCLIC LETTERS | 2020年 / 10卷 / 01期
关键词：
Chalcones; guanidine carbonate; Pyrimidine; Antioxidant activity; nitric oxide; CHEMISTRY; DESIGN;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new group of chalcones (2a-h) are synthesized by reacting substituted aromatic aldehydes derivatives and 4-nitro acetophenone in ethanol medium in presence of base. The chalcones (3a-h) underwent cyclization in the presence of guanidine carbonate to yield the title compounds substituted pyrimidine derivatives (3a-h). All the newly synthesized compounds were characterized on the basis of IR, H-1-NMR, and Mass spectral data. The final compounds were evaluated for their In-Vitro antioxidant activity by DPPH assay, Nitric oxide radical scavenging assay and super oxide scavenging assay. Some of the tested compounds 3b, 3d, 3e, 3g, 3h showed good antioxidant activity, when compared to standard ascorbic acid.
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页码：57 / 62
页数：6
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