Essential role of CD4+ T cells for the activation of group 2 innate lymphoid cells during respiratory syncytial virus infection in mice

被引：11

作者：

Han, Xu ^{[1
,2
]}

Bai, Song ^{[1
]}

Cui, Yulin ^{[1
]}

Zhu, Wenwen ^{[1
]}

Zhao, Na ^{[1
]}

Liu, Beixing ^{[1
]}

机构：

[1] China Med Univ, Dept Pathogen Biol, Sch Basic Med Sci, Shenyang, Peoples R China

[2] China Med Univ, Dept Med Oncol, Affiliated Hosp 1, Shenyang, Peoples R China

来源：

IMMUNOTHERAPY | 2019年 / 11卷 / 15期

基金：

中国国家自然科学基金;

关键词：

activation; CD4(+) T cells; group 2 innate lymphoid cells; IL-2; respiratory syncytial virus; NATURAL HELPER-CELLS; TYPE-2; IMMUNITY; LUNG; CYTOKINES; ASTHMA; IL-2; SENSITIZATION; INFLAMMATION; PATHWAY; PRODUCE;

D O I：

10.2217/imt-2019-0084

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: To investigate whether and how CD4(+ )T cells contribute to ILC2 activation during respiratory syncytial virus (RSV) infection. Methods: The methods of flow cytometry, quantitative PCR and ELISA were used in the present study. Results: Depletion of CD4(+) T cells diminished the numbers of lung ILC2s as well as their ability to produce type 2 cytokines. CD4(+ )T cell-mediated ILC2 activation is related to IL-2. The main cellular source of IL-2 was CD4(+ )T cells. Depletion of CD4(+) T cells decreased IL-2 levels in the lungs of RSV-infected mice. IL-2 can directly stimulate ILC2 proliferation and promote ILC2s to produce cytokines. Treatment of mice with neutralizing anti-IL-2 monoclonal antibodies diminished ILC2 activation. Conclusion: These results suggest that CD4(+) T cells contribute to RSV-induced ILC2 activation partly via producing IL-2.

引用

页码：1303 / 1313

页数：11

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