Sirolimus alters lung pathology and viral load following influenza A virus infection
被引:29
作者:
Alsuwaidi, Ahmed R.
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United Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
Alsuwaidi, Ahmed R.
[1
]
George, Junu A.
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United Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
George, Junu A.
[1
]
Almarzooqi, Saeeda
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机构:
United Arab Emirates Univ, Dept Pathol, Coll Med & Hlth Sci, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
Almarzooqi, Saeeda
[2
]
Hartwig, Stacey M.
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h-index: 0
机构:
Univ Iowa, Dept Pathol, Dept Microbiol & Immunol, Iowa City, IA 52242 USA
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA USAUnited Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
Hartwig, Stacey M.
[3
,4
]
Varga, Steven M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Pathol, Dept Microbiol & Immunol, Iowa City, IA 52242 USA
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA USAUnited Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
Varga, Steven M.
[3
,4
]
Souid, Abdul-Kader
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机构:
United Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
Souid, Abdul-Kader
[1
]
机构:
[1] United Arab Emirates Univ, Dept Pediat, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
[2] United Arab Emirates Univ, Dept Pathol, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
[3] Univ Iowa, Dept Pathol, Dept Microbiol & Immunol, Iowa City, IA 52242 USA
[4] Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA USA
Background: Inhibitors of mTOR, such as sirolimus, have been shown to induce thymus involution and inflammatory lung disease in mice. The latter effect supports the role of this serine/threonine kinase in ameliorating lung inflammation. Other studies have shown sirolimus reduces/delays lung disease associated with various strains of influenza A virus (IAV). Thus, the effects of mTOR inhibitors on influenza infection deserve further studies. Methods: Here, we examined the changes in lung viral copies, pathology and pulmonary function associated with IAV (A/PR/8/34) infection in mice treated with sirolimus. Results: Body weight loss peaked between days 6-11 post-infection and was more severe in IAV-infected mice that were administered sirolimus as compared to mice that received IAV alone (p = 0.030). Natural log viral gene copies, mean +/- SD per mg lung tissue, in IAV-infected mice that were administered sirolimus were 17.31 +/- 1.27 on day 4, 19.31 +/- 7.46 on day 10, and 0 on day 25. The corresponding number of copies in mice that received IAV alone were 18.56 +/- 0.95 on day 4 (p = 0.132), 1.52 +/- 1.39 on day 10 (p = 0.008), and 0 on day 25. Lung pathology was evident on days 4, 10, and 25 post infection, with mean +/- SD inflammatory score of 9.0 +/- 4.5 in IAV-infected mice that were administered sirolimus, as compared to 11.5 +/- 4.5 (p = 0.335) in mice received IAV alone (maximum score, 26.0). Impaired lung function was evident in IAV-infected mice on days 4 and 10, as demonstrated by increased airway resistance and decreased compliance. Conclusions: In this model, the effects of sirolimus on influenza infection included severe weight loss and modified viral replication, respiratory function and lung inflammation. The adverse events associated with sirolimus treatment are consistent with its potent immunosuppressive activity and, thus, preclude its use in IAV infection.
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Alsuwaidi, Ahmed R.
Almarzooqi, Saeeda
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h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pathol, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Almarzooqi, Saeeda
Albawardi, Alia
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h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pathol, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Albawardi, Alia
Benedict, Sheela
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h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Benedict, Sheela
Kochiyil, Jose
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h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Kochiyil, Jose
Mustafa, Farah
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h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Biochem, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Mustafa, Farah
Hartwig, Stacey M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USAUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Hartwig, Stacey M.
Varga, Steven M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USAUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Varga, Steven M.
Souid, Abdul-Kader
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Keating, Rachael
Hertz, Tomer
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Hertz, Tomer
Wehenkel, Marie
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Wehenkel, Marie
Harris, Tarsha L.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Harris, Tarsha L.
Edwards, Benjamin A.
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h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Edwards, Benjamin A.
McClaren, Jennifer L.
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h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
McClaren, Jennifer L.
Brown, Scott A.
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h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Brown, Scott A.
Surman, Sherri
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h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Surman, Sherri
Wilson, Zachary S.
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Wilson, Zachary S.
Bradley, Philip
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Bradley, Philip
Hurwitz, Julia
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h-index: 0
机构:St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Hurwitz, Julia
Chi, Hongbo
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h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Chi, Hongbo
Doherty, Peter C.
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h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Doherty, Peter C.
Thomas, Paul G.
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h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Thomas, Paul G.
McGargill, Maureen A.
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h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Alsuwaidi, Ahmed R.
Almarzooqi, Saeeda
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pathol, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Almarzooqi, Saeeda
Albawardi, Alia
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pathol, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Albawardi, Alia
Benedict, Sheela
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Benedict, Sheela
Kochiyil, Jose
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Kochiyil, Jose
Mustafa, Farah
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Biochem, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Mustafa, Farah
Hartwig, Stacey M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USAUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Hartwig, Stacey M.
Varga, Steven M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USAUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
Varga, Steven M.
Souid, Abdul-Kader
论文数: 0引用数: 0
h-index: 0
机构:
United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab EmiratesUnited Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pediat, Al Ain, U Arab Emirates
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Keating, Rachael
Hertz, Tomer
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Hertz, Tomer
Wehenkel, Marie
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Wehenkel, Marie
Harris, Tarsha L.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Harris, Tarsha L.
Edwards, Benjamin A.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Edwards, Benjamin A.
McClaren, Jennifer L.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
McClaren, Jennifer L.
Brown, Scott A.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Brown, Scott A.
Surman, Sherri
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Surman, Sherri
Wilson, Zachary S.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Wilson, Zachary S.
Bradley, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Bradley, Philip
Hurwitz, Julia
论文数: 0引用数: 0
h-index: 0
机构:St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Hurwitz, Julia
Chi, Hongbo
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Chi, Hongbo
Doherty, Peter C.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Doherty, Peter C.
Thomas, Paul G.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
Thomas, Paul G.
McGargill, Maureen A.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA