Asymmetric tremor due to possible valproic acid-aripiprazole interaction in a child with severe intellectual disability

Intellectual disability is a common neurodevelopmental disorder. Antipsychotic drugs, mood stabilizers drugs are often used in this group for behavioral problems. Tremor as a symptom can develop due to the use of both valproic acid and aripiprazole which is usually manifested as symmetrical.When valproate and ari-piprazole are administered together, there may be some change in plasma concentrations of aripiprazole and its metabolite but this change is thought to be related to the displacement in plasma proteins thus effect of both drugs on changes to steady state levels is very small and not clinically significant We report the case of a 15-year-old girl is that asymmetric tremor, which occurs after valproic acid is added to treatment while using aripiprazole, and the disappearance of asymmetric tremor after reducing the dose of aripiprazole.