Quantum dots increased fat storage in intestine of Caenorhabditis elegans by influencing molecular basis for fatty acid metabolism

被引:37
作者
Wu, Qiuli [1 ]
Zhi, Lingtong [1 ]
Qu, Yangyang [1 ]
Wang, Dayong [1 ]
机构
[1] Southeast Univ, Sch Med, Minist Educ, Key Lab Environm Engn, Nanjing, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
Caenorhabditis elegans; Quantum dots; Fat storage; Intestine; Fatty acid metabolism; MOTOR-NEURONS; TOXICITY; MODEL; TRANSLOCATION; NANOPARTICLES; EXPOSURE; CADMIUM; PM2.5;
D O I
10.1016/j.nano.2016.01.016
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Caenorhabditis elegans is a useful model animal for fat storage study. In nematodes, CdTe quantum dots (QDs) induced an increase in fat storage in intestine that is partially due to prolonged defecation cycle length, and not attributed to altered feeding or cadmium ion released from CdTe QDs. Moreover, CdTe QDs altered the molecular basis of both synthesis and degradation of fatty acid; however, CdTe QDs did not influence that of degradation of phospholipids. CdTe QDs increased expression of fasn-1 and pod-2 genes encoding enzymes required for fatty acid synthesis, and decreased expression of acs-2 and ech-1 genes encoding enzymes required for fatty acid beta-oxidation. The altered molecular basis of fatty acid synthesis or degradation by CdTe QDs acted in intestine to regulate fat storage. Our study highlights the potential of CdTe QDs in influencing lipid metabolism in certain organs or tissues in animals. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:1175 / 1184
页数:10
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