Treatment Effect of Bumetanide in Children With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

被引:15
|
作者
Wang, Tiantian [1 ]
Shan, Ling [1 ]
Miao, Chunyue [1 ]
Xu, Zhida [2 ]
Jia, Feiyong [1 ]
机构
[1] Jilin Univ, Dept Dev & Behav Pediat, Hosp 1, Changchun, Peoples R China
[2] GGz Centraal, Dept Psychiat, Amersfoort, Netherlands
来源
FRONTIERS IN PSYCHIATRY | 2021年 / 12卷
关键词
autism; bumetanide; children; treatment; meta-analysis; ADOLESCENTS; BEHAVIOR;
D O I
10.3389/fpsyt.2021.751575
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: The therapeutic effect of bumetanide on autism spectrum disorder (ASD) seems to be controversial. To obtain better evidence on the efficacy of bumetanide, a systematic review and meta-analysis were performed.Methods: Randomized, placebo-controlled trials (RCTs) of bumetanide treatment in children with ASD were identified through systematic review from database inception to January 17, 2021. Subsequently, a meta-analysis was carried out to examine the effect of bumetanide on the severity of symptoms of ASD as assessed by the Childhood Autism Rating Scale (CARS) and Social Responsive Scale (SRS); core symptoms according to criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 of the American Psychiatric Association [social affect (SA), restricted, repetitive patterns of behavior, interests, or activities (RRB) and sensory symptoms]; and the therapeutic effect as assessed by Clinical Global Impressions-Efficacy (CGI-E).Results: In total, six RCTs involving 496 participants with ASD were identified in our study. The results showed that bumetanide could significantly improve the severity of the ASD symptoms measured by CARS and SRS. There was also evidence that bumetanide had positive effect on the core symptoms of ASD such as the SA and RRB, but there was no statistically significant effect on sensory symptoms. A significant positive effect on CGI-E scores in ASD patients was also observed.Conclusion: Our meta-analysis provided some support that bumetanide could improve the symptoms of children with ASD. However, additional large-scale longitudinal studies that provide clearer information and better control for confounding factors are needed to confirm our findings.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Allergies in Children with Autism Spectrum Disorder: a Systematic Review and Meta-analysis
    Miyazaki, Celine
    Koyama, Momoko
    Ota, Erika
    Swa, Toshiyuki
    Amiya, Rachel M.
    Mlunde, Linda B.
    Tachibana, Yoshiyuki
    Yamamoto-Hanada, Kiwako
    Mori, Rintaro
    REVIEW JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2015, 2 (04) : 374 - 401
  • [2] Acupuncture for children with autism spectrum disorder: A systematic review and meta-analysis
    Lun, Tingting
    Lin, Shaoping
    Chen, Yuecai
    Zhao, Yunxuan
    Wang, Dexin
    Li, Li
    Yu, Jin
    MEDICINE, 2023, 102 (08) : E33079
  • [3] Allergies in Children with Autism Spectrum Disorder: a Systematic Review and Meta-analysis
    Celine Miyazaki
    Momoko Koyama
    Erika Ota
    Toshiyuki Swa
    Rachel M. Amiya
    Linda B. Mlunde
    Yoshiyuki Tachibana
    Kiwako Yamamoto-Hanada
    Rintaro Mori
    Review Journal of Autism and Developmental Disorders, 2015, 2 : 374 - 401
  • [4] Autism Spectrum Disorder and Obesity in Children: A Systematic Review and Meta-Analysis
    Sammels, Olivia
    Karjalainen, Louise
    Dahlgren, Jovanna
    Wentz, Elisabet
    OBESITY FACTS, 2022, 15 (03) : 305 - 320
  • [5] Aripiprazole in acute treatment of children and adolescents with autism spectrum disorder: a systematic review and meta-analysis
    Maneeton, Narong
    Maneeton, Benchalak
    Putthisri, Suwannee
    Suttajit, Sirijit
    Likhitsathian, Surinporn
    Srisurapanont, Manit
    NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2018, 14 : 3063 - 3072
  • [6] The Efficacy and Safety of Acupuncture for the Treatment of Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
    Lee, Boram
    Lee, Jihong
    Cheon, Jin-Hong
    Sung, Hyun-Kyung
    Cho, Seung-Hun
    Chang, Gyu Tae
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 2018
  • [7] Oxytocin treatment for core symptoms in children with autism spectrum disorder: a systematic review and meta-analysis
    Lifei Hu
    Xiaotian Du
    Zhongquan Jiang
    Chao Song
    Dong Liu
    European Journal of Clinical Pharmacology, 2023, 79 : 1357 - 1363
  • [8] Oxytocin treatment for core symptoms in children with autism spectrum disorder: a systematic review and meta-analysis
    Hu, Lifei
    Du, Xiaotian
    Jiang, Zhongquan
    Song, Chao
    Liu, Dong
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2023, 79 (10) : 1357 - 1363
  • [9] Motor Impairments in Children with Autism Spectrum Disorder: A Systematic Review and Meta-analysis
    Kangarani-Farahani, Melika
    Malik, Myrah Anum
    Zwicker, Jill G.
    JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2023, 54 (05) : 1774 - 1791
  • [10] Prevalence of autism spectrum disorder in Indian children: A systematic review and meta-analysis
    Chauhan, Anil
    Sahu, Jitendra K.
    Jaiswal, Nishant
    Kumar, Kiran
    Agarwal, Amit
    Kaur, Jasleen
    Singh, Sukhmanjeet
    Singh, Meenu
    NEUROLOGY INDIA, 2019, 67 (01) : 100 - 104