Prevalence of Endocrine and Metabolic Disorders in Subjects with Erectile Dysfunction: A Comparative Study

被引:69
作者
Maseroli, Elisa [1 ]
Corona, Giovanni [2 ]
Rastrelli, Giulia [1 ]
Lotti, Francesco [1 ]
Cipriani, Sarah [1 ]
Forti, Gianni [3 ]
Mannucci, Edoardo [4 ]
Maggi, Mario [1 ]
机构
[1] Univ Florence, Dept Expt Clin & Biomed Sci, Sexual Med & Androl Unit, I-50139 Florence, Italy
[2] Maggiore Bellaria Hosp, Dept Med, Endocrinol Unit, Azienda Usl, Bologna, Italy
[3] Univ Florence, Dept Expt Clin & Biomed Sci, Endocrinol Unit, Florence, Italy
[4] Careggi Hosp, Diabet Agcy, Florence, Italy
关键词
Hypogonadism; Hormones; Metabolic Syndrome; LATE-ONSET HYPOGONADISM; SEXUAL DYSFUNCTION; TESTOSTERONE DEFICIENCY; COMPENSATED HYPOGONADISM; DIABETES-MELLITUS; ELDERLY-MEN; AGING MEN; THERAPY; HYPERPROLACTINEMIA; METAANALYSIS;
D O I
10.1111/jsm.12832
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
IntroductionAlterations of gonadal, thyroid, and pituitary hormones, along with metabolic disorders, might be involved in causing erectile dysfunction (ED). AimThe prevalence of endocrine abnormalities in two different cohorts from the general and the symptomatic populations of Florence was compared. MethodsThe first group is a general population sample derived from a Florentine spin-off of the European Male Aging Study (EMAS cohort; n=202); the second group is a series of n=3,847 patients attending our clinic for ED (UNIFI cohort). ResultsBoth primary and secondary hypogonadism were more often observed in the UNIFI than in the EMAS cohort (2.8 vs. 0%; P<0.05 and 18.9 vs. 8%; P<0.001, respectively). However, only the second association retained statistical significance after adjusting for age. Compensated hypogonadism was more common in the EMAS cohort (4.4 vs. 8.1%; P<0.05). No statistically significant difference in the prevalence of overt thyroid disorders was observed. Conversely, subclinical hyperthyroidism was more prevalent in the EMAS cohort (2 vs. 4.1%, P<0.05). No significant difference in the prevalence of hyperprolactinemia was detected, while the prevalence of hypoprolactinemia was significantly higher in the UNIFI than in the EMAS cohort (28.2% vs. 17.8%, P=0.001), even after the adjustment for age, BMI, and testosterone (P=0.001). Central obesity (waist 102cm), impaired fasting glucose (IFG), and type 2 diabetes mellitus (T2DM) were more often detected in UNIFI patients (31.7 vs. 22.8%, P<0.05; 44.5 vs. 33.3%, P<0.05; 20.1% vs. 1.0%, P<0.001 in the UNIFI and EMAS cohort, respectively), even after adjusting for age. In contrast, the prevalence of overweight and obesity did not differ between the two groups. ConclusionT2DM, IFG, central obesity, secondary hypogonadism, and hypoprolactinemia are more frequent in subjects consulting for ED than in the general population of the same geographic area. Our data suggest that these conditions could play a central role in determining consultation for ED. Maseroli E, Corona G, Rastrelli G, Lotti F, Cipriani S, Forti G, Mannucci E, and Maggi M. Prevalence of endocrine and metabolic disorders in subjects with erectile dysfunction: A comparative study. J Sex Med 2015;12:956-965.
引用
收藏
页码:956 / 965
页数:10
相关论文
共 62 条
[1]   Sexual dysfunction 3 - Sexual dysfunction in men and women with endocrine disorders [J].
Bhasin, Shalender ;
Enzlin, Paul ;
Coviello, Andrea ;
Basson, Rosemary .
LANCET, 2007, 369 (9561) :597-611
[2]   Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline [J].
Bhasin, Shalender ;
Cunningham, Glenn R. ;
Hayes, Frances J. ;
Matsumoto, Alvin M. ;
Snyder, Peter J. ;
Swerdloff, Ronald S. ;
Montori, Victor M. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (06) :2536-2559
[3]   "It Takes Two to Tango": The Relational Domain in a Cohort of Subjects with Erectile Dysfunction (ED) [J].
Boddi, Valentina ;
Corona, Giovanni ;
Fisher, Alessandra Daphne ;
Mannucci, Edoardo ;
Ricca, Valdo ;
Sforza, Alessandra ;
Forti, Gianni ;
Maggi, Mario .
JOURNAL OF SEXUAL MEDICINE, 2012, 9 (12) :3126-3136
[4]   Hyperprolactinemia and sexual function in men: a short review [J].
Buvat, J .
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2003, 15 (05) :373-377
[5]   Testosterone Deficiency in Men: Systematic Review and Standard Operating Procedures for Diagnosis and Treatment [J].
Buvat, Jacques ;
Maggi, Mario ;
Guay, Andre ;
Torres, Luiz Otavio .
JOURNAL OF SEXUAL MEDICINE, 2013, 10 (01) :245-284
[6]   Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients [J].
Carani, C ;
Isidori, AM ;
Granata, A ;
Carosa, E ;
Maggi, M ;
Lenzi, A ;
Jannini, EA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (12) :6472-6479
[7]   Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases [J].
Cersosimo, Eugenio ;
DeFronzo, Ralph A. .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2006, 22 (06) :423-436
[8]   Subclinical thyroid disease [J].
Cooper, David S. ;
Biondi, Bernadette .
LANCET, 2012, 379 (9821) :1142-1154
[9]   The SUBITO-DE study: Sexual dysfunction in newly diagnosed Type 2 diabetes male patients [J].
Corona, G. ;
Giorda, C. B. ;
Cucinotta, D. ;
Guida, P. ;
Nada, E. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2013, 36 (10) :864-868
[10]   Diagnosis and treatment of late-onset hypogonadism: Systematic review and meta-analysis of TRT outcomes [J].
Corona, G. ;
Rastrelli, G. ;
Maggi, M. .
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 27 (04) :557-579