Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression

被引：6
作者：
Lee, Kanghee [1 ]
Han, Ji Won [1 ]
Kim, Ki Woong [1 ,2 ,3 ]
机构：
[1] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Seongnam, South Korea
[2] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea
[3] Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, Seoul, South Korea
来源：
PSYCHIATRY INVESTIGATION | 2017年 / 14卷 / 05期
关键词：
Alzheimer's disease; Major depressive disorder; Differential diagnosis; EEG; Theta; Beta; QUANTITATIVE ELECTROENCEPHALOGRAPHY; KOREAN VERSION; EEG; DEMENTIA; RELIABILITY; DIAGNOSIS; POWER;
D O I：
10.4306/pi.2017.14.5.708
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with major depressive disorder (MDD) and compared the EEG relative powers of 9 scalp regions. Compared to the MDD group, the AD group had a higher global theta relative power (p=0.021). In the MDD group, beta relative power was higher in the mid-central region than in the left or right central regions (p<0.01). The prediction model that included global theta relative power and regional beta index was able to discriminate AD from MDD (AUC=0.893, p=0.002). A combination of global theta relative power and intra-individual regional differences in beta may differentiate early AD from MDD with cognitive impairment.
引用
收藏
页码：708 / 711
页数：4
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