A Case of Unexplained Cerebral Sinus Thrombosis in a 22-Year-Old Obese Caucasian Woman

被引：5

作者：

Seheult, Jansen N. ^{[1
]}

Chibisov, Irina ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Inst Transfus Med, Med Ctr Hlth Syst, Pittsburgh, PA USA

来源：

LABORATORY MEDICINE | 2016年 / 47卷 / 03期

关键词：

plasminogen activator inhibitor 1; hypofibrinolysis; cerebral sinus thrombosis; plasminogen inactivators; venous thrombosis; gene promoter regions; PLASMINOGEN-ACTIVATOR INHIBITOR; PLASMA PROCARBOXYPEPTIDASE B; DEEP-VEIN THROMBOSIS; RISK-FACTOR; PAI-1; GENE; MOLECULAR-MECHANISMS; VENOUS THROMBOSIS; MYOCARDIAL-INFARCTION; 4G/5G GENOTYPE; POLYMORPHISM;

D O I：

10.1093/labmed/lmw023

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Herein, we present the case of a 22-year old obese Caucasian woman female with no acquired thrombophilic risk factors who was diagnosed with extensive cerebral sinus thrombosis. A detailed thrombophilia workup demonstrated persistently elevated plasminogen activator inhibitor 1 (PAI-1) activity levels, with an elevated PAI-1 antigen concentration and homozygosity for the PAI-1 4G allele (4G/4G genotype). The patient was treated with indefinite warfarin anticoagulation medication due to the unprovoked nature of her thrombotic event. Disturbances in the fibrinolytic system, in particular PAI-1, have been related to an increased risk of arterial and venous thrombosis. In this article, we discuss the pathophysiology of hypofibrinolysis associated with elevated PAI-1 levels and the PAI-1 4G/5G polymorphism.

引用

页码：233 / 240

页数：8

共 43 条

[1] Factor XIII, clot structure, thrombosis [J].

Bagoly, Zsuzsa ;

Koncz, Zsuzsa ;

Harsfalvi, Jolan ;

Muszbek, Laszlo .

THROMBOSIS RESEARCH, 2012, 129 (03) :382-387

[2] TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex [J].

Bajzar, L ;

Morser, J ;

Nesheim, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) :16603-16608

[3] PAI-1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs [J].

Balta, G ;

Altay, C ;

Gurgey, A .

AMERICAN JOURNAL OF HEMATOLOGY, 2002, 71 (02) :89-93

[4] Thrombosis of the deep cerebral veins with excessive bilateral infarction in a premature infant with the thrombogenic 4G/4G genotype of the plasminogen activator inhibitor-1 [J].

Baumeister, FAM ;

Auberger, K ;

Schneider, K .

EUROPEAN JOURNAL OF PEDIATRICS, 2000, 159 (04) :239-242

[5] PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) IN PLASMA AND PLATELETS [J].

BOOTH, NA ;

SIMPSON, AJ ;

CROLL, A ;

BENNETT, B ;

MACGREGOR, IR .

BRITISH JOURNAL OF HAEMATOLOGY, 1988, 70 (03) :327-333

[6] Molecular mechanisms of fibrinolysis [J].

Cesarman-Maus, G ;

Hajjar, KA .

BRITISH JOURNAL OF HAEMATOLOGY, 2005, 129 (03) :307-321

[7] Fibrinolysis and the control of blood coagulation [J].

Chapin, John C. ;

Hajjar, Katherine A. .

BLOOD REVIEWS, 2015, 29 (01) :17-24

[8] The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels [J].

Coffey, Christopher S. ;

Asselbergs, Folkert W. ;

Hebert, Patricia R. ;

Hillege, Hans L. ;

Li, Qing ;

Moore, Jason H. ;

van Gilst, Wiek H. .

CARDIOLOGY RESEARCH AND PRACTICE, 2011, 2011

[9]

CWIKEL BJ, 1984, J BIOL CHEM, V259, P6847

[10] GENETIC-VARIATION AT THE PLASMINOGEN-ACTIVATOR INHIBITOR-1 LOCUS IS ASSOCIATED WITH ALTERED LEVELS OF PLASMA PLASMINOGEN-ACTIVATOR INHIBITOR-1 ACTIVITY [J].

DAWSON, S ;

HAMSTEN, A ;

WIMAN, B ;

HENNEY, A ;

HUMPHRIES, S .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (01) :183-190

← 1 2 3 4 5 →