Vicinal C-Functionalization of Alkenes. Pd/Light-Induced Multicomponent Coupling Reactions Leading to Functionalized Esters and Lactones

被引：54

作者：

Fusano, Akira ^{[1
]}

Sumino, Shuhei ^{[1
]}

Fukuyama, Takahide ^{[1
]}

Ryu, Ilhyong ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Dept Chem, Grad Sch Sci, Osaka 5998531, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 08期

关键词：

ATOM-TRANSFER CARBONYLATION; VALENT METAL-COMPLEXES; CARBON-MONOXIDE; ALKYL IODIDES; RADICAL REACTIONS; OXIDATIVE ADDITION; CHEMISTRY; SYSTEM; BIS(METHOXYCARBONYLATION); HYDROXYMETHYLATION;

D O I：

10.1021/ol200536h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under photoirradiation conditions using a xenon light, and in the presence of PdCl2(PPh3)(2) as a catalyst, four-component coupling reactions comprising of alpha-substituted iodoalkanes, alkenes, carbon monoxide, and alcohols proceeded smoothly to give functionalized esters in good yields. When alkenyl alcohols were used as acceptor alkenes, three-component coupling reactions accompanied by intramolecular esterification proceeded to give lactones in good yields. The present reaction system represents the vicinal C-functionalization of alkenes.

引用

页码：2114 / 2117

页数：4

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