RANKL biology: bone metabolism, the immune system, and beyond

被引：392

作者：

Ono, Takehito ^{[1
,2
]}

Hayashi, Mikihito ^{[1
,2
]}

Sasaki, Fumiyuki ^{[1
,2
]}

Nakashima, Tomoki ^{[1
,2
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Cell Signaling, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138549, Japan

[2] Japan Agcy Med Res & Dev, Core Res Evolut Sci & Technol AMED CREST, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138549, Japan

来源：

INFLAMMATION AND REGENERATION | 2020年 / 40卷 / 01期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

RANKL; RANK; OPG; Bone; Immune system; Osteoimmunology; Organ development; Tumor; OSTEOCLAST DIFFERENTIATION FACTOR; KAPPA-B LIGAND; JUVENILE PAGETS-DISEASE; THYMIC EPITHELIAL-CELLS; INNATE LYMPHOID-CELLS; 2 UNRELATED PATIENTS; RECEPTOR ACTIVATOR; IDIOPATHIC HYPERPHOSPHATASIA; OSTEOPROTEGERIN-LIGAND; TANDEM DUPLICATION;

D O I：

10.1186/s41232-019-0111-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Receptor activator of NF-kappa B (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage-lineage cells into the bone-resorbing cells called osteoclasts. Because abnormalities in RANKL, its signaling receptor RANK, or decoy receptor osteoprotegerin (OPG) lead to bone diseases such as osteopetrosis, the RANKL/RANK/OPG system is essential for bone resorption. RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The essentiality of RANKL in the bone and the immune systems lies at the root of the field of "osteoimmunology." Furthermore, this cytokine functions beyond the domains of bone metabolism and the immune system, e.g., mammary gland and hair follicle formation, body temperature regulation, muscle metabolism, and tumor development. In this review, we will summarize the current understanding of the functions of the RANKL/RANK/OPG system in biological processes.

引用

页数：16

共 113 条

[1] RANKL-RANK interaction in immune regulatory systems [J].