Centenarians: An excellent example of resilience for successful ageing

被引：60

作者：

Borras, C. ^{[1
]}

Ingles, M. ^{[2
]}

Mas-Bargues, C. ^{[1
]}

Dromant, M. ^{[1
]}

Sanz-Ros, J. ^{[1
]}

Roman-Dominguez, A. ^{[1
]}

Gimeno-Mallench, L. ^{[1
]}

Gambini, J. ^{[1
]}

Vina, J. ^{[1
]}

机构：

[1] Univ Valencia, Fac Med, Dept Physiol, Freshage Res Grp,CIBERFES ISCIII, Valencia, Spain

[2] Univ Valencia, Fac Physiotherapy, Dept Physiotherapy, Freshage Res Grp,CIBERFES ISCIII, Valencia, Spain

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2020年 / 186卷

基金：

欧盟地平线“2020”;

关键词：

Healthy ageing; Extraordinary ageing; Successful ageing; Intrinsic capacity; QUALITY-OF-LIFE; OXIDATIVE STRESS; HUMAN LONGEVITY; MOUSE MODELS; OLDER-ADULTS; BURN INJURY; AGE; MICE; HEALTH; IMPAIRMENT;

D O I：

10.1016/j.mad.2019.111199

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Centenarians are remarkable not only because of their prolonged life, but also because they compress morbidity until the very last moments of their lives, thus being proposed as a model of successful, extraordinary ageing. From the medical viewpoint, centenarians do not escape the physiological decline or the age-related diseases or syndromes (i.e. frailty), but the rate of such processes is slow enough to be counterbalanced by their increased intrinsic capacity to respond to minor stresses of daily life (i.e. resilience). These new concepts are reviewed in this paper. Allostatic stresses lead to a chronic low-grade inflammation that has led to the proposal of the "inflammaging" theory of ageing and frailty. The biology of centenarians, described in this review, provides us with clues for intervention to promote healthy ageing in the general population. One of the major reasons for this healthy ageing has to do with the genetic signature that is specific for centenarians and certainly different from octogenarians who do not enjoy the extraordinary qualities of centenarians.

引用

页数：9

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