Amaryllidaceae, Lycopodiaceae Alkaloids and Coumarins-A Comparative Assessment of Safety and Pharmacological Activity

被引：1

作者：

Herbet, Mariola ^{[1
]}

Widelski, Jaroslaw ^{[2
]}

Piatkowska-Chmiel, Iwona ^{[1
]}

Pawlowski, Kamil ^{[1
]}

Dymek, Aleksandra ^{[3
]}

Mroczek, Tomasz ^{[3
]}

机构：

[1] Med Univ Lublin, Fac Pharm, Dept Toxicol, PL-20090 Lublin, Poland

[2] Med Univ Lublin, Dept Pharmacognosy Med Plant Garden, PL-20093 Lublin, Poland

[3] Med Univ Lublin, Dept Chem Nat Prod, PL-20093 Lublin, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 15期

关键词：

Alzheimer's disease; Amaryllidaceae alkaloids; Lycopodiaceae alkaloids; coumarins; acetylcholinesterase inhibitors; inflammation; GAMMA-GLUTAMYL-TRANSFERASE; ALZHEIMERS-DISEASE; TREM2; VARIANTS; CHOLINERGIC MODULATION; CORTICAL ACETYLCHOLINE; BUTYRYLCHOLINESTERASE; INFLAMMATION; MICE; RISK; ANTIOXIDANT;

D O I：

10.3390/jcm11154291

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The study aimed to evaluate the safety and pharmacological activity Amaryllidaceae, Lycopodiaceae alkaloids and coumarins obtained from Narcissus triandrus L., Lycopodium clavatum L., Lycopodium annotinum L., Huperzia selago L. and Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. In the in vivo studies. The influence of the tested compounds on the central nervous system of rats was assessed in behavioral tests (locomotor activity, Y-maze, passive avoidance). In order to investigate the mechanisms of action, biochemical determinations were performed (AChE activity, BChE activity, IL-1 beta, IL-6 concentration). In order to assess safety, the concentrations of AST, ALT, GGT and urea and creatinine were determined. The results of the conducted studies indicate a high safety profile of the tested compounds. Behavioral tests showed that they significantly improved rodent memory in a passive avoidance test. The results of biochemical studies showed that by reducing the activity of AChE and BChE and lowering the concentration of IL-1 beta and IL-6, the coumarin-rich Angelica dahurica extract shows the most promising potential for future therapeutic AD strategies.

引用

页数：20