Spatial fractionation of the dose in proton therapy: Proton minibeam radiation therapy

被引：16
作者：
De Marzi, L. [1 ,2 ]
Nauraye, C. [1 ]
Lansonneur, P. [1 ]
Pouzoulet, F. [3 ]
Patriarca, A. [1 ]
Schneiderde, T. [4 ,5 ,6 ]
Guardiola, C. [4 ,5 ,6 ]
Mammar, H. [1 ]
Dendale, R. [1 ]
Prezado, Y. [4 ,5 ,6 ]
机构：
[1] PSL Res Univ, Inst Curie, Ctr Protontherapie Orsay, Campus Univ,Batiment 101, F-91898 Orsay, France
[2] PSL Res Univ, Univ Paris Saclay, Inst Curie, INSERM,CNRS,U 1021,UMR 3347, Orsay, France
[3] Inst Curie, RadeXp Platform, Ctr Univ, F-91405 Orsay, France
[4] CNRS, IMNC, UMR 8165, 15 Rue Georges Clemenceau, F-91405 Orsay, France
[5] Univ Paris Diderot, UMR 8165, 15 Rue Georges Clemenceau, F-91405 Orsay, France
[6] Univ Paris Sud, UMR 8165, 15 Rue Georges Clemenceau, F-91405 Orsay, France
来源：
CANCER RADIOTHERAPIE | 2019年 / 23卷 / 6-7期
关键词：
Proton; Minibeam radiation therapy; Preclinical research; RAY MICROPLANAR BEAMS; BRAIN; RADIOTHERAPY; FEASIBILITY; TOLERANCE; TISSUE;
D O I：
10.1016/j.canrad.2019.08.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In radiation therapy, a renewed interest is emerging for the study of spatially fractionated irradiation. In this article, a few applications using spatial fractionation of the dose will be discussed with a focus on proton minibeam radiation therapy. Examples of calculated dose (1D profiles and 2D dose distributions) and biological evidence obtained so far will be presented for various spatially fractionated techniques GRID, micro- and minibeam radiation therapy. Recent results demonstrating that proton minibeam radiation therapy leads to an increase in normal tissues sparing will be discussed, which opens the door to a dose escalation in the tumour and a possibly efficient treatment of very radioresistant tumours. (C) 2019 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：677 / 681
页数：5
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