This study addresses a numerical analysis of heat transfer and fluid flow in an inclined half-annulus partially heated from above and filled with nanofluids. The conservation equations in cylindrical coordinates are solved using an in-house FORTRAN code based on the finite volume method coupled with multigrid acceleration. A localized heat source owing constant temperature is placed along the outer cylinder of the annular region. Water-based nanofluid containing various volume fractions of Au, Cu, CuO and Al2O3 nanoparticles is used to examine potential heat transfer enhancement in the annulus. The effective thermal conductivity and viscosity of nanofluid are calculated using the Maxwell-Garnetts (MG) and Brinkman models, respectively. Different configurations are considered and numerical simulations were performed for different governing parameters such as the Rayleigh number, the size gamma and/or location theta (p) of the heat source and inclination angle of enclosure alpha. It is found that the average Nusselt number exhibits an increasing trend as dual functions of the Rayleigh number and the solid volume fraction of the nanoparticles. The highest values of enhancement are obtained when using Au nanoparticles. Moreover, it is observed that the size, gamma, and location, theta (p) , of the heater source significantly affect the resulting convective flow. An optimum size of the heater source is manifested in which the average Nusselt number attains a minimum for a given Rayleigh number. Reliable correlations formulae expressing the average Nusselt number in terms of Ra, phi, gamma and theta (p) are established. Also for gamma = 180A degrees, we note that the change of inclination angle has a significant impact on the thermal and hydrodynamic flow field. It is shown that the minimum values of average Nusselt numbers are found to be at alpha(min) = 45A degrees, 90A degrees, 90A degrees for Ra = 10(3), 10(4) and 10(5), respectively. However, its maximum occurs at alpha(max) = 180A degrees for all Ra number.