Late effects after stem cell transplantation (SCT) in children - growth and hormones

被引：19

作者：

Ranke, MB ^{[1
]}

Schwarze, CP ^{[1
]}

Dopfer, R ^{[1
]}

Klingebiel, T ^{[1
]}

Scheel-Walter, HG ^{[1
]}

Lang, P ^{[1
]}

Niethammer, D ^{[1
]}

机构：

[1] Univ Tubingen, Dept Paediat, Tubingen, Germany

来源：

BONE MARROW TRANSPLANTATION | 2005年 / 35卷 / Suppl 1期

关键词：

SCT; late effects; growth; thyroid; puberty;

D O I：

10.1038/sj.bmt.1704853

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Stem cell transplantation (SCT) has established itself as a very successful therapy in often otherwise unbeatable disorders. In a subset of children and adolescents there are, how ever, late effects, often as a combination of the underlying disorder, its primary treatment and subsequent SCT. In children and adolescents, disorders of growth and the endocrine system have been observed to occur frequently. The assurance of normal growth, puberty, fertility and thyroid function - including the prevention of secondary malignancies - is of utmost importance for the overall success of treatment and the maintenance of quality of life. This, how ever, requires a systematic and structured follow-up programme for patients after SCT. Patients and their families need to be made familar with this concept early and physicians need to understand that such a system must be implemented as part of a comprehensive care.

引用

页码：S77 / S81

页数：5

共 27 条

[1] Pubertal development and growth after total-body irradiation and bone marrow transplantation for haematological malignancies [J].