Efficient chirality switching in the addition of diethylzinc to aldehydes in the presence of simple chiral α-amino amides

被引：49

作者：

Burguete, M. Isabel ^{[1
]}

Collado, Manuel ^{[1
]}

Escorihuela, Jorge ^{[1
]}

Luis, Santiago V. ^{[1
]}

机构：

[1] Univ Jaume 1, UAMOA, CSIC, Dept Inorgan & Organ Chem, E-12071 Castellon de La Plana, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 47期

关键词：

amino acids; asymmetric catalysis; chirality; homogeneous catalysis; ligand design;

D O I：

10.1002/anie.200702259

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) It works both ways: A very simple and efficient dual enantioselective control in the addition of diethylzinc to benzaldehyde can be achieved by using nickel complexes of chiral α-amino amide derivatives. Whereas complexes with 1:1 stoichiometries afford the S alcohol as the major enantiomer, 1:2 (metal/ligand) complexes lead to the predominant formation of the R enantiomer (see scheme). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9002 / 9005

页数：4

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