Plasma N-tau-methylhistidine concentration is a sensitive index of myofibrillar protein degradation during starvation in rats

被引：54
作者：
Nagasawa, T [1 ]
Yoshizawa, F [1 ]
Nishizawa, N [1 ]
机构：
[1] IWATE PREFECTURAL MORIOKA JR COLL, MORIOKA, IWATE 020, JAPAN
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 03期
关键词：
protein degradation; starvation; myofibrillar protein; 3-methylhistidine;
D O I：
10.1271/bbb.60.501
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Urinary excretion of N-tau-methylhistidine (MeHis) in rats was linearly elevated by starvation for 2 days. Plasma concentration of MeHis on day 1 and day 2 of starvation were increased 2.4- and 2.6-fold, respectively. The amount of released MeHis from the isolated muscles into medium during a 2-h incubation period was increased with starvation corresponded to the plasma MeHis concentration. The results of this study suggest that plasma MeHis is a sensitive index of myofibrillar protein degradation.
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页码：501 / 502
页数：2
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