Reprogramming Glial Cells into Functional Neurons for Neuro-regeneration: Challenges and Promise

被引：20

作者：

Wang, Fengchao ^{[1
]}

Cheng, Leping ^{[2
,3
,4
,5
]}

Zhang, Xiaohui ^{[1
]}

机构：

[1] Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

[2] Guangxi Med Univ, Ctr Translat Med, Key Lab Longev & Aging Related Dis, Chinese Minist Educ,Guangxi ASEAN Collaborat Inno, Nanning 530021, Peoples R China

[3] Guangxi Med Univ, Ctr Translat Med, Guangxi Key Lab Regenerat Med, Nanning 530021, Peoples R China

[4] Guangxi Med Univ, Sch Basic Med Sci, Dept Cell Biol & Genet, Nanning 530021, Peoples R China

[5] Guangxi Med Univ, Guangxi Hlth Commiss Key Lab Basic Res Brain Func, Nanning 530021, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2021年 / 37卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Direct cell-reprogramming; Glial cell-to-neuron conversion; Cross-differentiation neuronal regeneration; Brain repair; MULLER GLIA; ADULT NEUROGENESIS; NG2; GLIA; PARKINSONS-DISEASE; DIRECT CONVERSION; STEM-CELLS; MOUSE ASTROCYTES; PROGENITOR CELLS; MAMMALIAN BRAIN; IN-VITRO;

D O I：

10.1007/s12264-021-00751-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The capacity for neurogenesis in the adult mammalian brain is extremely limited and highly restricted to a few regions, which greatly hampers neuronal regeneration and functional restoration after neuronal loss caused by injury or disease. Meanwhile, transplantation of exogenous neuronal stem cells into the brain encounters several serious issues including immune rejection and the risk of tumorigenesis. Recent discoveries of direct reprogramming of endogenous glial cells into functional neurons have provided new opportunities for adult neuro-regeneration. Here, we extensively review the experimental findings of the direct conversion of glial cells to neurons in vitro and in vivo and discuss the remaining issues and challenges related to the glial subtypes and the specificity and efficiency of direct cell-reprograming, as well as the influence of the microenvironment. Although in situ glial cell reprogramming offers great potential for neuronal repair in the injured or diseased brain, it still needs a large amount of research to pave the way to therapeutic application.

引用

页码：1625 / 1636

页数：12

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