Synthesis of aromatic thioamide from nitrile without handling of gaseous hydrogen sulfide

被引：52
|
作者：
Manaka, A [1 ]
Sato, M [1 ]
机构：
[1] Taisho Pharmaceut Co Ltd, Med Res Labs, Med Chem Lab, Kita Ku, Saitama, Saitama 3319530, Japan
来源：
SYNTHETIC COMMUNICATIONS | 2005年 / 35卷 / 05期
关键词：
thioamides; nitriles; magnesium chloride;
D O I：
10.1081/SCC-200050393
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for synthesizing aromatic primary thioamides is described. Simple treatment of aromatic nitriles with sodium hydrogen sulfide and magnesium chloride in dimethylformamide (DMF) gave aromatic primary thioamides in yields of 80-99% without handling of hazardous hydrogen sulfide.
引用
收藏
页码：761 / 764
页数：4
相关论文
共 50 条
  • [31] SYNTHESIS OF METHYL MERCAPTAN FROM METHANOL AND HYDROGEN-SULFIDE ON ACIDIC CATALYSTS
    MASHKINA, AV
    PAUKSHTIS, EA
    YAKOVLEVA, VN
    KINETICS AND CATALYSIS, 1988, 29 (03) : 514 - 520
  • [32] Synthesis of methylmercaptan from methanol and hydrogen sulfide at elevated pressure on an industrial catalyst
    A. V. Mashkina
    Petroleum Chemistry, 2006, 46 : 28 - 33
  • [33] Versatile synthesis of molybdenum sulfide from confined spaces for efficient hydrogen evolution
    Chen, Liao
    Geng, Xiumei
    Yang, Lei
    Liang, Wentao
    Zhu, Hongli
    INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, 2017, 42 (43) : 26659 - 26666
  • [34] Synthesis of methylmercaptan from methanol and hydrogen sulfide at elevated pressure on an industrial catalyst
    Mashkina, A. V.
    PETROLEUM CHEMISTRY, 2006, 46 (01) : 28 - 33
  • [35] A SIMPLE SYNTHESIS OF 2-METHYL-1,4-DITHIACYCLOHEPTANE FROM DIALLYL SULFIDE AND HYDROGEN-SULFIDE
    MUSORIN, GK
    AMOSOVA, SV
    SHCHERBAKOV, VV
    BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR DIVISION OF CHEMICAL SCIENCE, 1990, 39 (11): : 2423 - 2423
  • [36] Gaseous Hydrogen Sulfide Protects against Myocardial Ischemia-Reperfusion Injury in Mice Partially Independent from Hypometabolism
    Snijder, Pauline M.
    de Boer, Rudolf A.
    Bos, Eelke M.
    van den Born, Joost C.
    Ruifrok, Willem-Peter T.
    Vreeswijk-Baudoin, Inge
    van Dijk, Marcory C. R. F.
    Hillebrands, Jan-Luuk
    Leuvenink, Henri G. D.
    van Goor, Harry
    PLOS ONE, 2013, 8 (05):
  • [37] Synthesis of dithienoquinazolines from pyrimidines via intramolecular nucleophilic aromatic substitution of hydrogen
    Egor V. Verbitskiy
    Ekaterina M. Dinastiya
    Anna A. Baranova
    Oleg S. Eltsov
    Gennady L. Rusinov
    Oleg N. Chupakhin
    Valery N. Charushin
    Chemistry of Heterocyclic Compounds, 2017, 53 : 1156 - 1160
  • [38] Synthesis of dithienoquinazolines from pyrimidines via intramolecular nucleophilic aromatic substitution of hydrogen
    Verbitskiy, Egor V.
    Dinastiya, Ekaterina M.
    Baranova, Anna A.
    Eltsov, Oleg S.
    Rusinov, Gennady L.
    Chupakhin, Oleg N.
    Charushin, Valery N.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2017, 53 (10) : 1156 - 1160
  • [39] ON DIRECT SYNTHESIS OF ALKYLCHLOROSILANES .3. SYNTHESIS OF ETHYLCHLOROSILANES FROM A MIXTURE OF ETHYL CHLORIDE AND GASEOUS HYDROGEN CHLORIDE
    CSAKVARI, B
    JENEI, S
    KNAUSZ, D
    TELEGDI, L
    ACTA CHIMICA ACADEMIAE SCIENTARIUM HUNGARICAE, 1965, 45 (01): : 31 - &
  • [40] Synthesis of Bactericides and Inhibitors of Hydrogen Sulfide Corrosion from Diethylamine and Piperylene and Isoprene Hydrochlorides
    Nafikova, E. V.
    Levashova, V. I.
    Dekhtyar', T. F.
    PETROLEUM CHEMISTRY, 2011, 51 (05) : 391 - 394
12345