Composite nanofiber mats consisting of hydroxyapatite and titania for biomedical applications

被引：40

作者：

Kim, Hong Mi ^{[1
]}

Chae, Won-Pyo ^{[1
]}

Chang, Ki-Whan ^{[2
]}

Chun, Sungsu ^{[3
]}

Kim, Sukyoung ^{[3
]}

Jeong, Yongsoo ^{[4
]}

Kang, Inn-Kyu ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Dept Polymer Sci & Engn, Taegu 702701, South Korea

[2] Daegu Hlth Coll, Dept Dent Technol, Taegu 702722, South Korea

[3] Yeungnam Univ, Sch Mat Sci & Engn, Gyongbuk, South Korea

[4] Korea Inst Mat Sci, Mat Proc Div, Chang Won 641010, South Korea

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2010年 / 94B卷 / 02期

关键词：

hydroxyapatite; titania; collagen; electrospinning; composite nanofibers; CELL-ADHESION; FIBER MATS; TISSUE; SCAFFOLDS; PHOSPHATE; MICROSTRUCTURE; GENERATION; FILM;

D O I：

10.1002/jbm.b.31664

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Composite nanofiber mats (HA/TiO2) consisting of hydroxyapatite (HA) and titania (TiO2) were fabricated via an electrospinning technique and then collagen (type I) was immobilized on the surface of the HA/TiO2 composite nanofiber mat to improve tissue compatibility. The structure and morphology of the collagen-immobilized composite nanofiber mat (HA/TiO2-col) was investigated using an X-ray diffractometer, electron spectroscopy for chemical analysis, and scanning electron microscope. The potential of the HA/TiO2-col composite nanofiber mat for use as a bone scaffold was assessed by an experiment with osteoblastic cells (MC3T3-E1) in terms of cell adhesion, proliferation, and differentiation. The results showed that the HA/TiO2-col composite nanofiber mats possess better cell adhesion and significantly higher proliferation and differentiation than untreated HA/TiO2 composite nanofiber mats. This result suggests that the HA/TiO2-col composite nanofiber mat has a high-potential for use in the field of bone regeneration and tissue engineering. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 94B: 380-387, 2010.

引用

页码：380 / 387

页数：8

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