Clinicopathological characteristics and outcome of primary sarcomatoid carcinoma of the gallbladder

被引:5
作者
Zou, Rui-Qi [1 ]
Hu, Hai-Jie [1 ]
Lv, Tian-Run [1 ]
Liu, Fei [1 ]
Ma, Wen-Jie [1 ]
Wang, Jun-Ke [1 ]
Dai, Yu-Shi [1 ]
Yang, Si-Qi [1 ]
Hu, Ya-Fei [1 ]
Li, Fu-Yu [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, Chengdu, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
基金
中国博士后科学基金;
关键词
gallbladder; sarcomatoid carcinoma; curative resection; adjuvant chemotherapy; S-1; ADJUVANT CHEMOTHERAPY; SURGICAL-MANAGEMENT; CLINICAL-FEATURES; GASTRIC-CANCER; PROGNOSIS; S-1; EFFICACY;
D O I
10.3389/fonc.2022.1009673
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PurposeOur study aims to examine the clinicopathological features, disease progression, management, and outcomes of gallbladder sarcomatoid carcinoma (GBSC) patients. MethodsBetween January 2000 and December 2020, 50 gallbladder cancer (GBC) patients who received surgical treatment and were pathologically verified as GBSC at our institution were enrolled. The clinical and pathological features and survival of these patients were retrospectively reviewed. ResultsThe median overall survival (OS) of GBSC patients was 14.5 months, and the 1-, 2- and 3-year OS rates were 68.0%, 32.0%, and 10.0%, respectively. The median progression-free survival (PFS) was 10.0 months, and the 1-, 2-, and 3-year PFS rates were 42.0%, 16.0%, and 2.0%, respectively. Patients who received radical resection had obviously better OS (18.0 vs. 7.0 months, P<0.001) and PFS (12.0 vs. 5.0 months, P<0.001) than those who underwent palliative resection. Multivariate analysis revealed that vascular invasion (P=0.033), curative operation (P<0.001) and postoperative chemotherapy (P=0.033) were independent risk factors for PFS. We further identified postoperative chemotherapy (P=0.010) and curative operation (P<0.001) as independent prognostic factors affecting the OS of GBSC patients. After curative surgery, patients who underwent S-1-based chemotherapy showed significantly longer recurrence-free survival (RFS) than those who underwent other chemotherapy regimens (20.0 vs 11.0 months, P=0.028). ConclusionGBSC patients always have aggressive biological behaviors and remarkably poor prognoses. Most GBSC patients are diagnosed in advanced stages, and timely radical operation together with postoperative chemotherapy is important. S-1-based chemotherapy may be a selectively efficient regimen to prolong the survival of GBSC patients.
引用
收藏
页数:11
相关论文
共 40 条
[1]   Predictors of postoperative early recurrence of extrahepatic bile duct cancer [J].
Akita, Masayuki ;
Ajiki, Tetsuo ;
Ueno, Kimihiko ;
Tsugawa, Daisuke ;
Hashimoto, Yu ;
Tanaka, Motofumi ;
Kido, Masahiro ;
Toyama, Hirochika ;
Fukumoto, Takumi .
SURGERY TODAY, 2020, 50 (04) :344-351
[2]   Gallbladder Cancer: expert consensus statement [J].
Aloia, Thomas A. ;
Jarufe, Nicolas ;
Javle, Milind ;
Maithel, Shishir K. ;
Roa, Juan C. ;
Adsay, Volkan ;
Coimbra, Felipe J. F. ;
Jarnagin, William R. .
HPB, 2015, 17 (08) :681-690
[3]   The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging [J].
Amin, Mahul B. ;
Greene, Frederick L. ;
Edge, Stephen B. ;
Compton, Carolyn C. ;
Gershenwald, Jeffrey E. ;
Brookland, Robert K. ;
Meyer, Laura ;
Gress, Donna M. ;
Byrd, David R. ;
Winchester, David P. .
CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (02) :93-99
[4]   Clinical significance of preoperative CA19-9 and lymph node metastasis in intrahepatic cholangiocarcinoma [J].
Asaoka, Tadafumi ;
Kobayashi, Shogo ;
Hanaki, Takehiko ;
Iwagami, Yoshifumi ;
Tomimaru, Yoshito ;
Akita, Hirofumi ;
Noda, Takehiro ;
Gotoh, Kunihito ;
Takeda, Yutaka ;
Tanemura, Masahiro ;
Doki, Yuichiro ;
Eguchi, Hidetoshi .
SURGERY TODAY, 2020, 50 (10) :1176-1186
[5]  
Baiu Ioana, 2018, JAMA, V320, P1294, DOI 10.1001/jama.2018.11815
[6]   Hepatobiliary Cancers, Version 2.2021 [J].
Benson III, Al B. ;
D'Angelica, Michael I. ;
Abbott, Daniel E. ;
Anaya, Daniel A. ;
Anders, Robert ;
Are, Chandrakanth ;
Bachini, Melinda ;
Borad, Mitesh ;
Brown, Daniel ;
Burgoyne, Adam ;
Chahal, Prabhleen ;
Chang, Daniel T. ;
Cloyd, Jordan ;
Covey, Anne M. ;
Glazer, Evan S. ;
Goyal, Lipika ;
Hawkins, William G. ;
Iyer, Renuka ;
Jacob, Rojymon ;
Kelley, R. Kate ;
Kim, Robin ;
Levine, Matthew ;
Palta, Manisha ;
Park, James O. ;
Raman, Steven ;
Reddy, Sanjay ;
Sahai, Vaibhav ;
Schefter, Tracey ;
Singh, Gagandeep ;
Stein, Stacey ;
Vauthey, Jean-Nicolas ;
Venook, Alan P. ;
Yopp, Adam ;
McMillian, Nicole R. ;
Hochstetler, Cindy ;
Darlow, Susan D. .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2021, 19 (05) :541-565
[7]   Pulmonary sarcomatoid carcinoma-a new hope [J].
Boland, J. M. ;
Mansfield, A. S. ;
Roden, A. C. .
ANNALS OF ONCOLOGY, 2017, 28 (07) :1417-1418
[8]   Sarcomatoid Carcinoma in the Head and Neck: A Population-Based Analysis of Outcome and Survival [J].
Ding, Lin ;
Bi, Zhuo-Fei ;
Yuan, Hang ;
Zhao, Xiao-Hui ;
Guan, Xue-Dan ;
Yao, He-Rui ;
Liu, Yi-Min .
LARYNGOSCOPE, 2021, 131 (02) :E489-E499
[9]   Efficacy of Immune Checkpoint Inhibitors in Lung Sarcomatoid Carcinoma [J].
Domblides, Charlotte ;
Leroy, Karen ;
Monnet, Isabelle ;
Mazieres, Julien ;
Barlesi, Fabrice ;
Gounant, Valerie ;
Baldacci, Simon ;
Mennecier, Bertrand ;
Toffart, Anne-Claire ;
Audigier-Valette, Clarisse ;
Doucet, Ludovic ;
Giroux-Leprieur, Etienne ;
Guisier, Florian ;
Ricordel, Charles ;
Molinier, Olivier ;
Perol, Maurice ;
Pichon, Eric ;
Robinet, Gilles ;
Templement-Grangerat, Dorine ;
Ruppert, Anne-Marie ;
Rabbe, Nathalie ;
Antoine, Martine ;
Wislez, Marie .
JOURNAL OF THORACIC ONCOLOGY, 2020, 15 (05) :860-866
[10]   Gallbladder cancer: a morphological and molecular update [J].
Goldin, Robert David ;
Carlos Roa, Juan .
HISTOPATHOLOGY, 2009, 55 (02) :218-229