On the Origin of Oscillopsia during Pedunculopontine Stimulation

被引：12

作者：

Jenkinson, Ned ^{[1
]}

Brittain, John-Stuart ^{[2
]}

Hicks, Stephen L. ^{[3
]}

Kennard, Christopher ^{[3
]}

Aziz, Tipu Z. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Surg Sci, Oxford, England

[2] Univ Oxford, Inst Biomed Engn, Oxford, England

[3] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

来源：

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY | 2012年 / 90卷 / 02期

基金：

英国医学研究理事会;

关键词：

Cerebellum; Deep brain stimulation; Electrical stimulation; Involuntary movements; Movement disorder surgery; Oscillopsia; Parkinson's disease; Pedunculopontine nucleus; Targeting; CAUDAL FASTIGIAL NUCLEUS; PURSUIT EYE-MOVEMENTS; PARKINSONS-DISEASE; MICROSTIMULATION; PARTICIPATION; MONKEYS; BRAIN;

D O I：

10.1159/000335871

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report a case of induced oscillopsia caused by deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN). Recent reports have described involuntary oscillopsia during DBS of the PPN that patients have described as trembling vision. Here we substantiate this observation using infra-red eye tracking. It has been suggested that this phenomenon might be used as an indicator of accurate targeting of the PPN with DBS. Our observations suggest that this phenomenon may not be related to a constricted anatomical structure and therefore such practise may be unwise. Scrutiny has led us to believe that the oscillopsia in our patient is not caused by direct stimulation of the oculomotor nerve as suggested in a previous report, but by stimulation of fibres in the uncinate fasciculus of the cerebellum and the superior cerebellar peduncle, which in turn stimulate the saccadic pre-motor neurones in the brainstem. Copyright (c) 2012 S. Karger AG, Basel

引用

页码：124 / 129

页数：6

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