Altered germinal center reaction and abnormal B cell peripheral maturation in PI3KR1-mutated patients presenting with HIGM-like phenotype

被引：55

作者：

Lougaris, Vassilios ^{[1
,2
]}

Faletra, Flavio ^{[3
]}

Lanzi, Gaetana ^{[4
,5
]}

Vozzi, Diego ^{[3
]}

Marcuzzi, Annalisa ^{[3
]}

Valencic, Erica ^{[3
]}

Piscianz, Elisa ^{[3
]}

Bianco, Anna Monica ^{[3
]}

Girardelli, Martina ^{[3
]}

Baronio, Manuela ^{[1
,2
]}

Loganes, Claudia ^{[3
]}

Fasth, Anders ^{[6
]}

Salvini, Filippo ^{[7
]}

Trizzino, Antonino ^{[8
]}

Moratto, Daniele ^{[4
,5
]}

Facchetti, Fabio ^{[9
]}

Giliani, Silvia ^{[4
,5
]}

Plebani, Alessandro ^{[1
,2
]}

Tommasini, Alberto ^{[3
]}

机构：

[1] Univ Brescia, Pediat Clin, Dept Clin & Expt Sci, Piazzale Spedali Civili 1, I-25123 Brescia, Italy

[2] Univ Brescia, Inst Mol Med A Nocivelli, Dept Clin & Expt Sci, I-25123 Brescia, Italy

[3] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

[4] Univ Brescia, Inst Mol Med A Nocivelli, Dept Mol & Translat Med, Lab Genet Disorders Childhood, I-25123 Brescia, Italy

[5] Univ Brescia, Dept Pathol, Dept Mol & Translat Med, Lab Genet Disorders Childhood, I-25123 Brescia, Italy

[6] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden

[7] Univ Milan, San Paolo Hosp, Dept Pediat, Milan, Italy

[8] ARNAS CIVICO, Dept Pediat Oncol & Hematol, Palermo, Italy

[9] Univ Brescia, Dept Mol & Translat Med, Pathol Unit, Brescia, Italy

来源：

CLINICAL IMMUNOLOGY | 2015年 / 159卷 / 01期

关键词：

PIK3R1; Hyper-IgM syndrome; B cells; Germinal Center (GC) reaction; HUMAN IMMUNODEFICIENCY; ACTIVATION; MUTATIONS;

D O I：

10.1016/j.clim.2015.04.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：33 / 36

页数：4

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