Apolipoprotein E-e4, Processing Speed, and White Matter Volume in a Genetically Enriched Sample of Midlife Adults

被引：13

作者：

Ready, Rebecca E. ^{[1
]}

Baran, B. ^{[1
]}

Chaudhry, M. ^{[1
]}

Schatz, K. ^{[1
]}

Gordon, J. ^{[1
]}

Spencer, R. M. C. ^{[1
]}

机构：

[1] Univ Massachusetts Amherst, Dept Psychol, Amherst, MA USA

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2011年 / 26卷 / 06期

关键词：

ApoE; MRI; processing speed; white matter; HEALTHY-INDIVIDUALS; HIPPOCAMPAL ATROPHY; ALZHEIMERS-DISEASE; MYELIN BREAKDOWN; APOE STATUS; E GENOTYPE; AGE; COGNITION; DECLINE; MEMORY;

D O I：

10.1177/1533317511421921

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Healthy midlife children of a parent with Alzheimer's disease ([AD] N = 23; 9 male) participated in neuropsychological testing, and magnetic resonance imaging (MRI) of brain volumetrics were obtained. In all, 35% of the sample were apolipoprotein E (ApoE)-e4 positive (n = 8; 5 male). The ApoE-e4 group exhibited significantly slower performances on an executive function and processing speed measure and had less white matter volume than the non-ApoE-e4 group. Lesser white matter volume was significantly correlated with slower processing speed. Processing speed and changes in white matter volume might be indicators of preclinical decline in AD.

引用

页码：463 / 468

页数：6

共 41 条

[1]

[Anonymous], 2001, DELIS KAPLAN EXECUTI

[2]

[Anonymous], 2009, WECHSLER MEMORY SCAL

[3] Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals - Implications for cognitive decline, and dementia [J].

Bartzokis, G ;

Lu, PH ;

Geschwind, DH ;

Edwards, N ;

Mintz, J ;

Cummings, JL .

ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (01) :63-72

[4] Apolipoprotein e affects both myelin breakdown and cognition: Implications for age-related trajectories of decline into dementia [J].

Bartzokis, George ;

Lu, Po H. ;

Geschwind, Daniel H. ;

Tingus, Kathleen ;

Huang, Danny ;

Mendez, Mario F. ;

Edwards, Nancy ;

Mintz, Jim .

BIOLOGICAL PSYCHIATRY, 2007, 62 (12) :1380-1387

[5] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[6] APOE-ε4 count predicts age when prevalence of AD increases, then declines -: The Cache County Study [J].

Breitner, JCS ;

Wyse, BW ;

Anthony, JC ;

Welsh-Bohmer, KA ;

Steffens, DC ;

Norton, MC ;

Tschanz, JT ;

Plassman, BL ;

Meyer, MR ;

Skoog, I ;

Khachaturian, A .

NEUROLOGY, 1999, 53 (02) :321-331

[7]

Caselli R J, 2004, Neurology, V62, P1990

[8] Longitudinal Modeling of Age-Related Memory Decline and the APOE ε4 Effect [J].

Caselli, Richard J. ;

Dueck, Amylou C. ;

Osborne, David ;

Sabbagh, Marwan N. ;

Connor, Donald J. ;

Ahern, Geoffrey L. ;

Baxter, Leslie C. ;

Rapcsak, Steven Z. ;

Shi, Jiong ;

Woodruff, Bryan K. ;

Locke, Dona E. C. ;

Snyder, Charlene Hoffman ;

Alexander, Gene E. ;

Rademakers, Rosa ;

Reiman, Eric M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (03) :255-263

[9] Correlations between apolipoprotein E ε4 gene dose and whole brain atrophy rates [J].

Chen, Kewei ;

Reiman, Eric M. ;

Alexander, Gene E. ;

Caselli, Richard J. ;

Gerkin, Richard ;

Bandy, Daniel ;

Domb, Alisa ;

Osborne, David ;

Fox, Nick ;

Crum, William R. ;

Saunders, Ann M. ;

Hardy, John .

AMERICAN JOURNAL OF PSYCHIATRY, 2007, 164 (06) :916-921

[10] Cortical surface-based analysis - I. Segmentation and surface reconstruction [J].

Dale, AM ;

Fischl, B ;

Sereno, MI .

NEUROIMAGE, 1999, 9 (02) :179-194

← 1 2 3 4 5 →