MitoMiner: a data warehouse for mitochondrial proteomics data

被引：71

作者：

Smith, Anthony C. ^{[1
]}

Blackshaw, James A. ^{[1
]}

Robinson, Alan J. ^{[1
]}

机构：

[1] Med Res Council Mitochondrial Biol Unit, Cambridge CB2 0XY, England

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / D1期

基金：

英国医学研究理事会;

关键词：

INTEGRATED DATABASE; COMPLEX-I; IDENTIFICATION; DROSOPHILA; PROTEINS; DISEASES; STORAGE; GENES;

D O I：

10.1093/nar/gkr1101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MitoMiner (http://mitominer.mrc-mbu.cam.ac.uk) is a data warehouse for the storage and analysis of mitochondrial proteomics data gathered from publications of mass spectrometry and green fluorescent protein tagging studies. In MitoMiner, these data are integrated with data from UniProt, Gene Ontology, Online Mendelian Inheritance in Man, HomoloGene, Kyoto Encyclopaedia of Genes and Genomes and PubMed. The latest release of MitoMiner stores proteomics data sets from 46 studies covering 11 different species from eumetazoa, viridiplantae, fungi and protista. MitoMiner is implemented by using the open source InterMine data warehouse system, which provides a user interface allowing users to upload data for analysis, personal accounts to store queries and results and enables queries of any data in the data model. MitoMiner also provides lists of proteins for use in analyses, including the new MitoMiner mitochondrial proteome reference sets that specify proteins with substantial experimental evidence for mitochondrial localization. As further mitochondrial proteomics data sets from normal and diseased tissue are published, MitoMiner can be used to characterize the variability of the mitochondrial proteome between tissues and investigate how changes in the proteome may contribute to mitochondrial dysfunction and mitochondrial-associated diseases such as cancer, neurodegenerative diseases, obesity, diabetes, heart failure and the ageing process.

引用

页码：D1160 / D1167

页数：8

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