Chondroprotective Effect of Alendronate in a Rabbit Model of Osteoarthritis

被引：72
作者：
Shirai, Takaaki [1 ]
Kobayashi, Masahiko [1 ]
Nishitani, Kohei [1 ]
Satake, Tsuyoshi [1 ]
Kuroki, Hiroshi [2 ]
Nakagawa, Yasuaki [3 ]
Nakamura, Takashi [1 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Orthoped Surg, Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Univ, Grad Sch Med, Dept Phys Therapy, Sakyo Ku, Kyoto 6068507, Japan
[3] Kyoto Med Ctr, Dept Orthoped Surg, Fushimi Ku, Kyoto 6128555, Japan
来源：
JOURNAL OF ORTHOPAEDIC RESEARCH | 2011年 / 29卷 / 10期
关键词：
alendronate; osteoarthritis; cartilage; knee; subchondral bone; OSTEOPHYTE FORMATION; TRABECULAR BONE; CARTILAGE; BISPHOSPHONATE; CHONDROCYTE; EXPRESSION; PREVENTION; ARTHRITIS; LIGAND; JOINT;
D O I：
10.1002/jor.21394
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
The aim of this study was to determine how alendronate (ALN) alters cartilage degeneration and periarticular bone quality in a rabbit anterior cruciate ligament transection (ACLT) model of osteoarthritis (OA). Thirty rabbits underwent an ACLT on the left knee and a sham operation on the right knee. Fifteen rabbits received weekly subcutaneous injections of ALN (0.14 mg/kg) and 15 rabbits (the control [cont] group) received saline. Animal knees were divided into four groups: cont/sham, cont/ACLT, ALN/sham, and ALN/ACLT. Histological, radiological, and immunohistochemical indices were evaluated for each group. Bone volume ratios by micro-computed tomography showed that ALN prevented periarticular bone loss. Histologically, the cont/ACLT group had significantly worse cartilage damage than the cant/sham group 12 weeks after the surgery. However, the ALN/ACLT group had mild cartilage degeneration compared with that of the ALN/sham group. Immunohistochemical analysis showed that ALN suppressed the expression of matrix metalloproteinase-13, interleukin-1 beta, type-X collagen, vascular endothelial growth factor, and receptor activator of nuclear factor kappa B ligand in OA cartilage. ALN had a chondroprotective effect in an experimental rabbit model of OA. (C) 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:1572-1577, 2011
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页码：1572 / 1577
页数：6
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