Poly(3-hydroxybutyrate) and Human Microbiota (Review)

被引：8

作者：

Bonartsev, A. P. ^{[1
,2
]}

Voinova, V. V. ^{[2
]}

Bonartseva, G. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Bach Inst Biochem, Fundamentals Biotechnol Fed Res Ctr, Moscow 119071, Russia

[2] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119234, Russia

来源：

APPLIED BIOCHEMISTRY AND MICROBIOLOGY | 2018年 / 54卷 / 06期

基金：

俄罗斯科学基金会;

关键词：

polyhydroxyalkanoates; poly(3-hydroxybutyrate); biopolymer; oligomers; microbiota; transfection; translocation; type IV secretory system; intestine; POLY-BETA-HYDROXYBUTYRATE; PEPTIC-ULCER DISEASE; IV SECRETION SYSTEM; IN-VITRO; LEGIONELLA-PNEUMOPHILA; BIODEGRADABLE PATCH; ESCHERICHIA-COLI; POLYHYDROXYBUTYRATE SYNTHESIS; POLY-3-HYDROXYBUTYRATE PHB; INTRACELLULAR BACTERIA;

D O I：

10.1134/S0003683818060066

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Natural polyhydroxyalkanoates (PHAs) and their synthetic analogs are widely used in medicine, including the production of biodegradable medical devices (prostheses, patches, stents, and plugs) intended for regenerative intestinal surgery. The possibility of biosynthesis and biodegradation of PHAs, primarily, their most common representative, poly(3-hydroxybutyrate) (PHB), by different symbiotic and infectious human and animal bacteria, particularly, multiple bacteria of intestinal microbiota, as well as the physiological role of biopolymer in bacterial cells, is discussed in detail in the review. The review also focuses on the problem of endogenous PHB in humans and animals. The assumption that microbiota bacteria can be a source of endogenous PHB is also discussed. In addition, the use of PHAs in regenerative intestine surgery is considered.

引用

页码：547 / 568

页数：22

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