Pathophysiology of hemolytic transfusion reactions

被引：48

作者：

Davenport, RD ^{[1
]}

机构：

[1] Univ Michigan, Univ Hosp, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

SEMINARS IN HEMATOLOGY | 2005年 / 42卷 / 03期

关键词：

D O I：

10.1053/j.seminhematol.2005.04.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hemolytic transfusion reactions (HTR) are systemic reactions provoked by immunologic red blood cell (RBC) incompatibility. Clinical and experimental observations of such reactions indicate that they proceed through phases of humoral immune reaction, activation of phagocytes, productions of cytokine mediators, and wide-ranging cellular responses. HTR have many features in common with the systemic inflammatory response syndrome (SIRS). Knowledge of the pathophysiologic mechanisms in HTR suggest that newer biological agents that target complement intermediates or proinflammatory cytokines may be effective agents in the treatment of severe HTRs. © 2005 Elsevier Inc. All rights reserved.

引用

页码：165 / 168

页数：4

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