Smooth Muscle Cell Differentiation In Vitro Models and Underlying Molecular Mechanisms

被引：73

作者：

Xie, Changqing ^{[1
]}

Ritchie, Raquel P. ^{[1
]}

Huang, Huarong ^{[1
]}

Zhang, Jifeng ^{[1
]}

Chen, Y. Eugene ^{[1
]}

机构：

[1] Univ Michigan, Med Ctr, Dept Internal Med, Ctr Cardiovasc, Ann Arbor, MI 48109 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2011年 / 31卷 / 07期

关键词：

vascular biology; vascular muscle; EMBRYONIC STEM-CELLS; SERUM RESPONSE FACTOR; NEURAL CREST CELLS; GROWTH-FACTOR-BETA; RETINOIC ACID; CARCINOMA-CELLS; GENE-EXPRESSION; SECONDARY HEART; MARKER GENES; MUTANT MICE;

D O I：

10.1161/ATVBAHA.110.221101

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Development of in vitro models by which to study smooth muscle cell (SMC) differentiation has been hindered by some peculiarities intrinsic to these cells, namely their different embryological origins and their ability to undergo phenotypic modulation in cell culture. Although many in vitro models are available for studying SMC differentiation, careful consideration should be taken so that the model chosen fits the questions being posed. In this review, we summarize several well-established in vitro models available to study SMC differentiation from stem cells and outline novel mechanisms recently identified as underlying SMC differentiation programs. (Arterioscler Thromb Vasc Biol. 2011; 31:1485-1494.)

引用

页码：1485 / 1494

页数：10

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