Evaluation of remifentanil for control of haemodynamic response to tracheal intubation

被引:31
|
作者
McAtamney, D
O'Hare, R
Hughes, D
Carabine, U
Mirakhur, R
机构
[1] Queens Univ Belfast, Dept Anaesthet, Belfast BT9 7BL, Antrim, North Ireland
[2] Royal Hosp Trust, Dept Clin Anaesthesia, Belfast BT12 6BA, Antrim, North Ireland
关键词
intubation; tracheal; technique; analgesics; remifentanil; blood pressure; drug effect; anaesthetic techniques; induction;
D O I
10.1046/j.1365-2044.1998.00601.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We have studied the effect of three bolus doses of remifentanil on the haemodynamic response to laryngoscopy and tracheal intubation. Using a double-blind design, 80 ASA I or 2 patients presenting for elective surgery received saline placebo or remifentanil 0.25, 0.5 or 1.0 mu g.kg(-1) by random allocation. Anaesthesia was induced with thiopentone 5-7 mg.kg(-1) and followed immediately by the study medication given as a bolus over 30s. Muscle relaxation was provided with rocuronium 0.75 mg.kg(-1). The patients' tracheas were intubated under direct laryngoscopy 1 min later. Noninvasive arterial blood pressure and heart rate were recorded immediately before induction of anaesthesia and then at intervals until 5 min after tracheal intubation. There was a significant increase in heart rate (p < 0.01) and systolic arterial pressure (p < 0.01) in all groups after tracheal intubation. However, this was short-lived and of a smaller magnitude in the remifentanil 1 mu g.kg(-1) group in which the increase was significantly lower than in the control group (p < 0.01).
引用
收藏
页码:1223 / 1227
页数:5
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