We have studied the effect of three bolus doses of remifentanil on the haemodynamic response to laryngoscopy and tracheal intubation. Using a double-blind design, 80 ASA I or 2 patients presenting for elective surgery received saline placebo or remifentanil 0.25, 0.5 or 1.0 mu g.kg(-1) by random allocation. Anaesthesia was induced with thiopentone 5-7 mg.kg(-1) and followed immediately by the study medication given as a bolus over 30s. Muscle relaxation was provided with rocuronium 0.75 mg.kg(-1). The patients' tracheas were intubated under direct laryngoscopy 1 min later. Noninvasive arterial blood pressure and heart rate were recorded immediately before induction of anaesthesia and then at intervals until 5 min after tracheal intubation. There was a significant increase in heart rate (p < 0.01) and systolic arterial pressure (p < 0.01) in all groups after tracheal intubation. However, this was short-lived and of a smaller magnitude in the remifentanil 1 mu g.kg(-1) group in which the increase was significantly lower than in the control group (p < 0.01).
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Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South KoreaChung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South Korea
Kim, W. J.
Kang, H.
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Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South KoreaChung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South Korea
Kang, H.
Yang, S. Y.
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Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South KoreaChung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South Korea
Yang, S. Y.
Shin, H. Y.
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Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South KoreaChung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South Korea
Shin, H. Y.
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Baek, C. W.
Jung, Y. H.
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Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South KoreaChung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South Korea
Jung, Y. H.
Woo, Y. C.
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Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South KoreaChung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South Korea
Woo, Y. C.
In, J. Y.
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Dongguk Univ, Coll Med, Ilsan Hosp, Dept Anesthesiol & Pain Med, Goyang 411773, South KoreaChung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 156755, South Korea