N-trifluoroacetyl sialyl phosphite donors for the synthesis of α(2 → 9) oligosialic acids

被引：57

作者：

Lin, CC ^{[1
]}

Huang, KT

Lin, CC ^{[1
]}

机构：

[1] Acad Sinica, Inst Chem, Taipei 115, Taiwan

[2] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

[3] Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 19期

关键词：

D O I：

10.1021/ol0515210

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of alpha(2 -> 9) oligosialic acids is developed using phosphite sialyl donors that are protected with a C-5 N-trifluoroacetyl (NHTFA) substituent. Compared with conventional donors, these donors gave a higher degree of alpha-anomeric selectivity during glycosidic bond formation and better yields during iterative sialylation in the synthesis of oligosialic acids.

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页码：4169 / 4172

页数：4

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