N-trifluoroacetyl sialyl phosphite donors for the synthesis of α(2 → 9) oligosialic acids

被引：57
作者：
Lin, CC [1 ]
Huang, KT
Lin, CC [1 ]
机构：
[1] Acad Sinica, Inst Chem, Taipei 115, Taiwan
[2] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
[3] Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 19期
关键词：
D O I：
10.1021/ol0515210
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the synthesis of alpha(2 -> 9) oligosialic acids is developed using phosphite sialyl donors that are protected with a C-5 N-trifluoroacetyl (NHTFA) substituent. Compared with conventional donors, these donors gave a higher degree of alpha-anomeric selectivity during glycosidic bond formation and better yields during iterative sialylation in the synthesis of oligosialic acids.
引用
收藏
页码：4169 / 4172
页数：4
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