ZO Proteins and Redox-Dependent Processes

被引：63

作者：

Gonzalez-Mariscal, Lorenza ^{[1
]}

Quiros, Miguel ^{[1
]}

Diaz-Coranguez, Monica ^{[1
]}

机构：

[1] CINVESTAV, Dept Physiol Biophys & Neurosci, Ctr Res & Adv Studies, Mexico City 07360, DF, Mexico

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 15卷 / 05期

关键词：

TIGHT-JUNCTION PROTEIN; BLOOD-BRAIN-BARRIER; MICROVASCULAR ENDOTHELIAL-CELLS; ZONULA OCCLUDENS PROTEIN-1; KINASE-LIKE DOMAIN; PDZ-DOMAIN; OXIDATIVE STRESS; EPITHELIAL-CELLS; TYROSINE PHOSPHORYLATION; HYDROGEN-PEROXIDE;

D O I：

10.1089/ars.2011.3913

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significance: ZO-1, ZO-2, and ZO-3 are scaffold proteins of the tight junction (TJ) that belong to the MAGUK protein family characterized for exhibiting PDZ, SH3, and GuK domains. ZO proteins are present only in multicellular organisms, being the placozoa the first to have them. ZO proteins associate among themselves and with other integral and adaptor proteins of the TJ, of the ZA and of gap junctions, as with numerous signaling proteins and the actin cytoskeleton. ZO proteins are also present at the nucleus of proliferating cells. Recent Advances: Oxidative stress disassembles the TJs of endothelial and epithelial cells. Critical Issues: Oxidative stress alters ZO proteins expression and localization, in conditions like hypoxia, bacterial and viral infections, vitamin deficiencies, age-related diseases, diabetes and inflammation, alcohol and tobacco consumption. Future Directions: Molecules present in the signaling pathways triggered by oxidative stress can be targets for therapeutic intervention. Antioxid. Redox Signal. 15, 1235-1253.

引用

收藏

页码：1235 / 1253

页数：19

相关论文

共 200 条

[1] Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells [J].

Abbruscato, TJ ;

Lopez, SP ;

Mark, KS ;

Hawkins, BT ;

Davis, TP .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (12) :2525-2538

[2] Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein [J].

Adachi, Makoto ;

Inoko, Akihito ;

Hata, Masaki ;

Furuse, Kyoko ;

Umeda, Kazuaki ;

Itoh, Masahiko ;

Tsukita, Shoichiro .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (23) :9003-9015

[3] Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos) [J].

Aho, Sirpa ;

Lupo, Julien ;

Coly, Pierre-Alain ;

Sabine, Amelie ;

Castellazzi, Marc ;

Morand, Patrice ;

Sergeant, Alain ;

Manet, Evelyne ;

Boyer, Veronique ;

Gruffat, Henri .

BIOLOGY OF THE CELL, 2009, 101 (06) :319-334

[4] Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms [J].

Andreeva, AY ;

Piontek, J ;

Blasig, IE ;

Utepbergenov, DI .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2006, 38 (02) :222-233

[5] Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions [J].

Atkinson, KJ ;

Rao, RK .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 280 (06) :G1280-G1288

[6] Tight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase C [J].

Avila-Flores, A ;

Rendón-Huerta, E ;

Moreno, J ;

Islas, S ;

Betanzos, A ;

Robles-Flores, M ;

Gonzalez-Mariscal, L .

BIOCHEMICAL JOURNAL, 2001, 360 (02) :295-304

[7] The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression [J].

Balda, MS ;

Matter, K .

EMBO JOURNAL, 2000, 19 (09) :2024-2033

[8] ASSEMBLY OF THE TIGHT JUNCTION - THE ROLE OF DIACYLGLYCEROL [J].

BALDA, MS ;

GONZALEZMARISCAL, L ;

MATTER, K ;

CEREIJIDO, M ;

ANDERSON, JM .

JOURNAL OF CELL BIOLOGY, 1993, 123 (02) :293-302

[9] The SH3 domain of the tight junction protein ZO-1 binds to a serine protein kinase that phosphorylates a region C-terminal to this domain [J].

Balda, MS ;

Anderson, JM ;

Matter, K .

FEBS LETTERS, 1996, 399 (03) :326-332

[10] Nicotine induces oxidative stress and activates nuclear transcription factor kappa B in rat mesencephalic cells [J].

Barr, Johnny ;

Sharma, Chidananda S. ;

Sarkar, Shubhashish ;

Wise, Kimberly ;

Dong, Liang ;

Periyakaruppan, Adaikkappan ;

Ramesh, Govindarajan T. .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2007, 297 (1-2) :93-99

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