Effect of AV3V lesions on Fos expression and cell size increases in magnocellular neurons of the rat hypothalamus during chronic dehydration

被引：12

作者：

Miyata, S ^{[1
]}

Matsunaga, W ^{[1
]}

Mondoh, H ^{[1
]}

Nakashima, T ^{[1
]}

Kiyohara, T ^{[1
]}

机构：

[1] KYOTO INST TECHNOL,DEPT APPL BIOL,SAKYO KU,KYOTO 606,JAPAN

来源：

NEUROSCIENCE RESEARCH | 1996年 / 26卷 / 02期

关键词：

AV3V lesions; Fos; cell size; magnocellular neurons; hypothalamus;

D O I：

10.1016/S0168-0102(96)01099-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of osmotic stimulation on Fos expression and cell size increase in the supraoptic nucleus were evaluated in intact, sham-operated, and AV3V-lesioned rats. Fos-positive neurons were found mainly in the AV3V regions and the hypothalamic magnocellular neurons in the forebrain in dehydrated intact rats. Intraperitoneal injection of hypertonic saline and chronic dehydration induced a significant increase in number of Fos-positive neurons in the supraoptic nucleus of intact and sham-operated rats. AV3V lesions completely abolished the expression of Fos in SON neurons of rats that were intraperitoneally injected with hypertonic saline and were chronically dehydrated. Chronic dehydration increased significantly cell size of the OXT and AVP magnocelluar neurons in intact and sham-operated rats. However, there was no increase in cell size of those in the AV3V-lesioned rats. These results demonstrate that neural input derived from AV3V regions plays a significant role in causing Fos expression and structural changes such as cell size increase in the hypothalamic magnocellular neurons with osmotic stimulation.

引用

页码：149 / 156

页数：8

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