共 67 条
AGEs, RAGE, and Diabetic Retinopathy
被引:190
作者:

Zong, Hongliang
论文数: 0 引用数: 0
h-index: 0
机构:
Queens Univ Belfast, Ctr Vis & Vasc Sci, Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland Queens Univ Belfast, Ctr Vis & Vasc Sci, Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland

论文数: 引用数:
h-index:
机构:

Stitt, Alan W.
论文数: 0 引用数: 0
h-index: 0
机构:
Queens Univ Belfast, Ctr Vis & Vasc Sci, Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland Queens Univ Belfast, Ctr Vis & Vasc Sci, Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland
机构:
[1] Queens Univ Belfast, Ctr Vis & Vasc Sci, Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland
关键词:
Diabetic retinopathy;
Advanced glycation end products (AGEs);
Receptor for AGEs (RAGE);
Inflammation;
RAGE blockade;
GLYCATION END-PRODUCTS;
ENDOTHELIAL GROWTH-FACTOR;
CYTOPLASMIC DOMAIN;
SIGNALING PATHWAYS;
FACTOR EXPRESSION;
OXIDATIVE STRESS;
CELL-SURFACE;
RECEPTOR;
DYSFUNCTION;
ACTIVATION;
D O I:
10.1007/s11892-011-0198-7
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Diabetic retinopathy is a major diabetic complication with a highly complex etiology. Although there are many pathways involved, it has become established that chronic exposure of the retina to hyperglycemia gives rise to accumulation of advanced glycation end products (AGEs) that play an important role in retinopathy. In addition, the receptor for AGEs (RAGE) is ubiquitously expressed in various retinal cells and is upregulated in the retinas of diabetic patients, resulting in activation of pro-oxidant and proinflammatory signaling pathways. This AGE-RAGE axis appears to play a central role in the sustained inflammation, neurodegeneration, and retinal microvascular dysfunction occurring during diabetic retinopathy. The nature of AGE formation and RAGE signaling bring forward possibilities for therapeutic intervention. The multiple components of the AGE-RAGE axis, including signal transduction, formation of ligands, and the end-point effectors, may be promising targets for strategies to treat diabetic retinopathy.
引用
收藏
页码:244 / 252
页数:9
相关论文
共 67 条
[21]
AMINOGUANIDINE TREATMENT INHIBITS THE DEVELOPMENT OF EXPERIMENTAL DIABETIC-RETINOPATHY
[J].
HAMMES, HP
;
MARTIN, S
;
FEDERLIN, K
;
GEISEN, K
;
BROWNLEE, M
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1991, 88 (24)
:11555-11558

HAMMES, HP
论文数: 0 引用数: 0
h-index: 0
机构:
YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA

MARTIN, S
论文数: 0 引用数: 0
h-index: 0
机构:
YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA

FEDERLIN, K
论文数: 0 引用数: 0
h-index: 0
机构:
YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA

GEISEN, K
论文数: 0 引用数: 0
h-index: 0
机构:
YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA

BROWNLEE, M
论文数: 0 引用数: 0
h-index: 0
机构:
YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA
[22]
Advanced glycation end products induce expression of vascular endothelial growth factor by retinal Muller cells
[J].
Hirata, C
;
Nakano, K
;
Nakamura, N
;
Kitagawa, Y
;
Shigeta, H
;
Hasegawa, G
;
Ogata, M
;
Ikeda, T
;
Sawa, H
;
Nakamura, K
;
Ienaga, K
;
Obayashi, H
;
Kondo, M
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1997, 236 (03)
:712-715

Hirata, C
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Nakano, K
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Nakamura, N
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Kitagawa, Y
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Shigeta, H
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Hasegawa, G
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Ogata, M
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Ikeda, T
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Sawa, H
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Nakamura, K
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Ienaga, K
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Obayashi, H
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

Kondo, M
论文数: 0 引用数: 0
h-index: 0
机构: KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN
[23]
Transgenic expression of human S100A12 induces structural airway abnormalities and limited lung inflammation in a mouse model of allergic inflammation
[J].
Bowman, M. A. Hofmann
;
Heydemann, A.
;
Gawdzik, J.
;
Shilling, R. A.
;
Camoretti-Mercado, B.
.
CLINICAL AND EXPERIMENTAL ALLERGY,
2011, 41 (06)
:878-889

Bowman, M. A. Hofmann
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA

Heydemann, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA

Gawdzik, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA

Shilling, R. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Med, Sect Pulm & Crit Care, Chicago, IL 60637 USA Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA

Camoretti-Mercado, B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Med, Sect Pulm & Crit Care, Chicago, IL 60637 USA Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA
[24]
Identification, classification, and expression of RAGE gene splice variants
[J].
Hudson, Barry I.
;
Carter, Angela M.
;
Harja, Evis
;
Kalea, Anastasia Z.
;
Arriero, Maria
;
Yang, Hojin
;
Grant, Peter J.
;
Schmidt, Ann Marie
.
FASEB JOURNAL,
2008, 22 (05)
:1572-1580

Hudson, Barry I.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Carter, Angela M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leeds, Leeds Inst Genet Hlth & Therapeut, Acad Unit Mol Vasc Med, Leeds, W Yorkshire, England Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Harja, Evis
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Kalea, Anastasia Z.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Arriero, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Yang, Hojin
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Grant, Peter J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leeds, Leeds Inst Genet Hlth & Therapeut, Acad Unit Mol Vasc Med, Leeds, W Yorkshire, England Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Schmidt, Ann Marie
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA
[25]
Interaction of the RAGE Cytoplasmic Domain with Diaphanous-1 Is Required for Ligand-stimulated Cellular Migration through Activation of Rac1 and Cdc42
[J].
Hudson, Barry I.
;
Kalea, Anastasia Z.
;
Arriero, Maria del Mar
;
Harja, Evis
;
Boulanger, Eric
;
D'Agati, Vivette
;
Schmidt, Ann Marie
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2008, 283 (49)
:34457-34468

Hudson, Barry I.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Kalea, Anastasia Z.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Arriero, Maria del Mar
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Harja, Evis
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA

论文数: 引用数:
h-index:
机构:

D'Agati, Vivette
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Div Surg Sci, Dept Pathol, New York, NY 10032 USA Columbia Univ, Med Ctr, Div Surg Sci, Dept Surg, New York, NY 10032 USA

论文数: 引用数:
h-index:
机构:
[26]
Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways
[J].
Huttunen, HJ
;
Fages, C
;
Rauvala, H
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1999, 274 (28)
:19919-19924

Huttunen, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Helsinki, Inst Biotechnol, Mol Neurobiol Lab, FIN-00014 Helsinki, Finland

Fages, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Helsinki, Inst Biotechnol, Mol Neurobiol Lab, FIN-00014 Helsinki, Finland

Rauvala, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Helsinki, Inst Biotechnol, Mol Neurobiol Lab, FIN-00014 Helsinki, Finland
[27]
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products
[J].
Kaji, Yuichi
;
Usui, Tomohiko
;
Ishida, Susumu
;
Yamashiro, Kenji
;
Moore, Tara C. B.
;
Moore, Jonathan
;
Yamamoto, Yasuhiko
;
Yamamoto, Hiroshi
;
Adamis, Anthony P.
.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,
2007, 48 (02)
:858-865

Kaji, Yuichi
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA

Usui, Tomohiko
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA

Ishida, Susumu
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA

Yamashiro, Kenji
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA

Moore, Tara C. B.
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA

Moore, Jonathan
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA

Yamamoto, Yasuhiko
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA

Yamamoto, Hiroshi
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA

Adamis, Anthony P.
论文数: 0 引用数: 0
h-index: 0
机构: Eyetech, Res Ctr, New York, NY 10036 USA
[28]
RAGE: a novel biological and genetic marker for vascular disease
[J].
Kalea, Anastasia Z.
;
Schmidt, Ann Marie
;
Hudson, Barry I.
.
CLINICAL SCIENCE,
2009, 116 (7-8)
:621-637

Kalea, Anastasia Z.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Schmidt, Ann Marie
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA

Hudson, Barry I.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Div Surg Sci, Dept Surg, New York, NY 10032 USA
[29]
KIOM-79 prevents methyglyoxal-induced retinal pericyte apoptosis in vitro and in vivo
[J].
Kim, Ohn Soon
;
Kim, Junghyun
;
Kim, Chan-Sik
;
Kim, Nan Hee
;
Kim, Jin Sook
.
JOURNAL OF ETHNOPHARMACOLOGY,
2010, 129 (03)
:285-292

Kim, Ohn Soon
论文数: 0 引用数: 0
h-index: 0
机构:
Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea

Kim, Junghyun
论文数: 0 引用数: 0
h-index: 0
机构:
Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea

Kim, Chan-Sik
论文数: 0 引用数: 0
h-index: 0
机构:
Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea

Kim, Nan Hee
论文数: 0 引用数: 0
h-index: 0
机构:
Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea

Kim, Jin Sook
论文数: 0 引用数: 0
h-index: 0
机构:
Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea Korea Inst Oriental Med, Diabet Complicat Res Ctr, Div Tradit Korean Med Integrated Res, Taejon 305811, South Korea
[30]
Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-Based micronutrients
[J].
Kowluru, Renu A.
;
Kanwar, Mamta
;
Chan, Pooi-See
;
Zhang, Jiang Ping
.
ARCHIVES OF OPHTHALMOLOGY,
2008, 126 (09)
:1266-1272

Kowluru, Renu A.
论文数: 0 引用数: 0
h-index: 0
机构:
Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA

Kanwar, Mamta
论文数: 0 引用数: 0
h-index: 0
机构:
Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA

Chan, Pooi-See
论文数: 0 引用数: 0
h-index: 0
机构:
Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA

Zhang, Jiang Ping
论文数: 0 引用数: 0
h-index: 0
机构:
Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA