Antimicrobial Properties of Chitosan and Its Derivatives

被引:33
作者
Masson, Mar [1 ]
机构
[1] Univ Iceland, Sch Hlth Sci, Fac Pharmaceut Sci, Reykjavik, Iceland
来源
CHITOSAN FOR BIOMATERIALS III: STRUCTURE-PROPERTY RELATIONSHIPS | 2021年 / 287卷
关键词
Antibacterial; Antifungal; Antimicrobial; Chemical modification; Degree of acetylation (DA); Degree of substitution (DS); Mechanism of action; Molecular weight (Mw); Structure-activity relationship; NONNATURAL BRANCHED POLYSACCHARIDES; CULTURED GLYCINE-MAX; ANTIBACTERIAL ACTIVITY; GLYCOL CHITOSAN; CARBOXYMETHYL CHITOSAN; MOLECULAR-WEIGHT; N; N-TRIMETHYL CHITOSAN; TRIMETHYLATED CHITOSAN; QUATERNIZED CHITOSAN; THERMOSENSITIVE HYDROGEL;
D O I
10.1007/12_2021_104
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The investigations of chitosan as an antimicrobial substance came into focus in the 1990s. The number of publications on this topic has been rapidly increasing since then, with more than 2,500 papers published in 2020. Initially, the interest was mainly related to potential applications in agriculture and food products, but currently, the emphasis on the medical use of chitosan and chitosan derivatives is continuously increasing. Common derivatives of chitosan include carboxymethyl chitosan (CMC), N,N,N-trimethyl chitosan (TMC), N-(2-hydroxyl), propyl-3-trimethyl ammonium chitosan chloride (HTCC), hydroxypropyl chitosan (HPC), and glycol chitosan. All of these derivatives have been investigated as antimicrobial polymers in various applications, but most such studies involve using the cationic derivatives TMC and HTCC. Countless other antimicrobial chitosan derivatives have been reported in at least one publication. Many researchers have studied the antimicrobial mechanism of action against bacteria and fungi and found that the polymers affect the cell membrane, but the details of the interaction are still debated. Other studies have indicated intracellular nucleic acids, surface proteins, and lipopolysaccharides as possible targets. Various applications, including plant protection, food preservation, wound treatment, and water purification, have been considered to utilize the antimicrobial properties of chitosan-based materials. Structure-activity relationship studies are helpful to elucidate the function and importance of different structural characteristics that may influence activity, including the degree of acetylation (DA), charge, the structure of the substituted, degree of substitution (DS), and molecular weight (Mw).
引用
收藏
页码:131 / 168
页数:38
相关论文
共 185 条
[1]   Mucoadhesive chitosan/gelatin films for buccal delivery of propranolol hydrochloride [J].
Abruzzo, Angela ;
Bigucci, Federica ;
Cerchiara, Teresa ;
Cruciani, Federica ;
Vitali, Beatrice ;
Luppi, Barbara .
CARBOHYDRATE POLYMERS, 2012, 87 (01) :581-588
[2]   Recent advances on chitosan-based micro- and nanoparticles in drug delivery [J].
Agnihotri, SA ;
Mallikarjuna, NN ;
Aminabhavi, TM .
JOURNAL OF CONTROLLED RELEASE, 2004, 100 (01) :5-28
[3]   HTCC-Modified Nanoclay for Tissue Engineering Applications: A Synergistic Cell Growth and Antibacterial Efficiency [J].
Aliabadi, Majid ;
Dastjerdi, Roya ;
Kabiri, Kourosh .
BIOMED RESEARCH INTERNATIONAL, 2013, 2013
[4]   FUNGICIDAL EFFECT OF CHITOSAN ON FUNGI OF VARYING CELL-WALL COMPOSITION [J].
ALLAN, CR ;
HADWIGER, LA .
EXPERIMENTAL MYCOLOGY, 1979, 3 (03) :285-287
[5]   Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system [J].
Amidi, M ;
Romeijn, SG ;
Borchard, G ;
Junginger, HE ;
Hennink, WE ;
Jiskoot, W .
JOURNAL OF CONTROLLED RELEASE, 2006, 111 (1-2) :107-116
[6]   Efficient water soluble O-carboxymethyl chitosan nanocarrier for the delivery of curcumin to cancer cells [J].
Anitha, A. ;
Maya, S. ;
Deepa, N. ;
Chennazhi, K. P. ;
Nair, S. V. ;
Tamura, H. ;
Jayakumar, R. .
CARBOHYDRATE POLYMERS, 2011, 83 (02) :452-461
[7]   Synthesis, characterization, cytotoxicity and antibacterial studies of chitosan, O-carboxymethyl and N,O-carboxymethyl chitosan nanoparticles [J].
Anitha, A. ;
Rani, V. V. Divya ;
Krishna, R. ;
Sreeja, V. ;
Selvamurugan, N. ;
Nair, S. V. ;
Tamura, H. ;
Jayakumar, R. .
CARBOHYDRATE POLYMERS, 2009, 78 (04) :672-677
[8]   A review on applications of chitosan-based Schiff bases [J].
Antony, R. ;
Arun, T. ;
Manickam, S. Theodore David .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 129 :615-633
[9]   Synthesis and fungicidal activity of new N,O-acyl chitosan derivatives [J].
Badawy, MEI ;
Rabea, EI ;
Rogge, TM ;
Stevens, CV ;
Smagghe, G ;
Steurbaut, W ;
Höfte, M .
BIOMACROMOLECULES, 2004, 5 (02) :589-595
[10]   An innovative water-soluble biopolymer improves efficacy of ciclopirox nail lacquer in the management of onychomycosis [J].
Baran, R. ;
Tosti, A. ;
Hartmane, I. ;
Altmeyer, P. ;
Hercogova, J. ;
Koudelkova, V. ;
Ruzicka, T. ;
Combemale, P. ;
Mikazans, I. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2009, 23 (07) :773-781